Fluorine »
PDB 4iju-4j0t »
4ixe »
Fluorine in PDB 4ixe: Pcdhfr-Nadph-270
Enzymatic activity of Pcdhfr-Nadph-270
All present enzymatic activity of Pcdhfr-Nadph-270:
1.5.1.3;
1.5.1.3;
Protein crystallography data
The structure of Pcdhfr-Nadph-270, PDB code: 4ixe
was solved by
V.Cody,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 36.64 / 1.54 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 36.708, 42.719, 58.481, 90.00, 93.59, 90.00 |
| R / Rfree (%) | 17.7 / 22 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Pcdhfr-Nadph-270
(pdb code 4ixe). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Pcdhfr-Nadph-270, PDB code: 4ixe:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Pcdhfr-Nadph-270, PDB code: 4ixe:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 4ixe
Go back to
Fluorine Binding Sites List in 4ixe
Fluorine binding site 1 out
of 3 in the Pcdhfr-Nadph-270
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Pcdhfr-Nadph-270 within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 4ixe
Go back to
Fluorine Binding Sites List in 4ixe
Fluorine binding site 2 out
of 3 in the Pcdhfr-Nadph-270
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Pcdhfr-Nadph-270 within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 4ixe
Go back to
Fluorine Binding Sites List in 4ixe
Fluorine binding site 3 out
of 3 in the Pcdhfr-Nadph-270
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Pcdhfr-Nadph-270 within 5.0Å range:
|
Reference:
A.Gangjee,
O.A.Namjoshi,
S.Raghavan,
S.F.Queener,
R.L.Kisliuk,
V.Cody.
Design, Synthesis, and Molecular Modeling of Novel Pyrido[2,3-D]Pyrimidine Analogues As Antifolates; Application of Buchwald-Hartwig Aminations of Heterocycles. J.Med.Chem. V. 56 4422 2013.
ISSN: ISSN 0022-2623
PubMed: 23627352
DOI: 10.1021/JM400086G
Page generated: Mon Jul 14 22:27:23 2025
ISSN: ISSN 0022-2623
PubMed: 23627352
DOI: 10.1021/JM400086G
Last articles
Fe in 2YXOFe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
