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Fluorine in PDB 4izw: The E41L Mutant of the Amidase From Nesterenkonia Sp. AN1 Showing Covalent Addition of the Acetamide Moiety of Fluoroacetamide at the Active Site Cysteine
Enzymatic activity of The E41L Mutant of the Amidase From Nesterenkonia Sp. AN1 Showing Covalent Addition of the Acetamide Moiety of Fluoroacetamide at the Active Site Cysteine
All present enzymatic activity of The E41L Mutant of the Amidase From Nesterenkonia Sp. AN1 Showing Covalent Addition of the Acetamide Moiety of Fluoroacetamide at the Active Site Cysteine:
3.5.1.4;
3.5.1.4;
Protein crystallography data
The structure of The E41L Mutant of the Amidase From Nesterenkonia Sp. AN1 Showing Covalent Addition of the Acetamide Moiety of Fluoroacetamide at the Active Site Cysteine, PDB code: 4izw
was solved by
S.W.Kimani,
B.T.Sewell,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 42.87 / 1.60 |
| Space group | C 2 2 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 75.626, 114.382, 64.767, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 18.3 / 21.3 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the The E41L Mutant of the Amidase From Nesterenkonia Sp. AN1 Showing Covalent Addition of the Acetamide Moiety of Fluoroacetamide at the Active Site Cysteine
(pdb code 4izw). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the The E41L Mutant of the Amidase From Nesterenkonia Sp. AN1 Showing Covalent Addition of the Acetamide Moiety of Fluoroacetamide at the Active Site Cysteine, PDB code: 4izw:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the The E41L Mutant of the Amidase From Nesterenkonia Sp. AN1 Showing Covalent Addition of the Acetamide Moiety of Fluoroacetamide at the Active Site Cysteine, PDB code: 4izw:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 4izw
Go back to
Fluorine Binding Sites List in 4izw
Fluorine binding site 1 out
of 3 in the The E41L Mutant of the Amidase From Nesterenkonia Sp. AN1 Showing Covalent Addition of the Acetamide Moiety of Fluoroacetamide at the Active Site Cysteine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of The E41L Mutant of the Amidase From Nesterenkonia Sp. AN1 Showing Covalent Addition of the Acetamide Moiety of Fluoroacetamide at the Active Site Cysteine within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 4izw
Go back to
Fluorine Binding Sites List in 4izw
Fluorine binding site 2 out
of 3 in the The E41L Mutant of the Amidase From Nesterenkonia Sp. AN1 Showing Covalent Addition of the Acetamide Moiety of Fluoroacetamide at the Active Site Cysteine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of The E41L Mutant of the Amidase From Nesterenkonia Sp. AN1 Showing Covalent Addition of the Acetamide Moiety of Fluoroacetamide at the Active Site Cysteine within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 4izw
Go back to
Fluorine Binding Sites List in 4izw
Fluorine binding site 3 out
of 3 in the The E41L Mutant of the Amidase From Nesterenkonia Sp. AN1 Showing Covalent Addition of the Acetamide Moiety of Fluoroacetamide at the Active Site Cysteine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of The E41L Mutant of the Amidase From Nesterenkonia Sp. AN1 Showing Covalent Addition of the Acetamide Moiety of Fluoroacetamide at the Active Site Cysteine within 5.0Å range:
|
Reference:
S.W.Kimani,
R.Hunter,
M.Vlok,
J.Watermeyer,
B.T.Sewell.
Covalent Modifications of the Active Site Cysteine Occur As A Result of Mutating the Glutamate of the Catalytic Triad in the Amidase From Nesterenkonia Sp. To Be Published.
Page generated: Thu Aug 1 02:40:42 2024
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