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Atomistry » Fluorine » PDB 4l3o-4luv » 4lmn | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 4l3o-4luv » 4lmn » |
Fluorine in PDB 4lmn: Crystal Structure of MEK1 Kinase Bound to GDC0973Enzymatic activity of Crystal Structure of MEK1 Kinase Bound to GDC0973
All present enzymatic activity of Crystal Structure of MEK1 Kinase Bound to GDC0973:
2.7.12.2; Protein crystallography data
The structure of Crystal Structure of MEK1 Kinase Bound to GDC0973, PDB code: 4lmn
was solved by
M.H.Ultsch,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4lmn:
The structure of Crystal Structure of MEK1 Kinase Bound to GDC0973 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of MEK1 Kinase Bound to GDC0973
(pdb code 4lmn). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of MEK1 Kinase Bound to GDC0973, PDB code: 4lmn: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 4lmnGo back to![]() ![]()
Fluorine binding site 1 out
of 3 in the Crystal Structure of MEK1 Kinase Bound to GDC0973
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 3 in 4lmnGo back to![]() ![]()
Fluorine binding site 2 out
of 3 in the Crystal Structure of MEK1 Kinase Bound to GDC0973
![]() Mono view ![]() Stereo pair view
Fluorine binding site 3 out of 3 in 4lmnGo back to![]() ![]()
Fluorine binding site 3 out
of 3 in the Crystal Structure of MEK1 Kinase Bound to GDC0973
![]() Mono view ![]() Stereo pair view
Reference:
G.Hatzivassiliou,
J.R.Haling,
H.Chen,
K.Song,
S.Price,
R.Heald,
J.F.Hewitt,
M.Zak,
A.Peck,
C.Orr,
M.Merchant,
K.P.Hoeflich,
J.Chan,
S.M.Luoh,
D.J.Anderson,
M.J.Ludlam,
C.Wiesmann,
M.Ultsch,
L.S.Friedman,
S.Malek,
M.Belvin.
Mechanism of Mek Inhibition Determines Efficacy in Mutant Kras- Versus Braf-Driven Cancers. Nature V. 501 232 2013.
Page generated: Mon Jul 14 23:03:16 2025
ISSN: ISSN 0028-0836 PubMed: 23934108 DOI: 10.1038/NATURE12441 |
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