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Atomistry » Fluorine » PDB 4mm9-4ncg » 4nc5 » |
Fluorine in PDB 4nc5: Human Sialidase 2 in Complex with 2,3-Difluorosialic Acid (Covalent Intermediate)Enzymatic activity of Human Sialidase 2 in Complex with 2,3-Difluorosialic Acid (Covalent Intermediate)
All present enzymatic activity of Human Sialidase 2 in Complex with 2,3-Difluorosialic Acid (Covalent Intermediate):
3.2.1.18; Protein crystallography data
The structure of Human Sialidase 2 in Complex with 2,3-Difluorosialic Acid (Covalent Intermediate), PDB code: 4nc5
was solved by
S.Buchini,
F.-X.Gallat,
I.R.Greig,
J.-H.Kim,
S.Wakatsuki,
L.M.G.Chavas,
S.G.Withers,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Sialidase 2 in Complex with 2,3-Difluorosialic Acid (Covalent Intermediate)
(pdb code 4nc5). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Human Sialidase 2 in Complex with 2,3-Difluorosialic Acid (Covalent Intermediate), PDB code: 4nc5: Fluorine binding site 1 out of 1 in 4nc5Go back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Human Sialidase 2 in Complex with 2,3-Difluorosialic Acid (Covalent Intermediate)
![]() Mono view ![]() Stereo pair view
Reference:
S.Buchini,
F.X.Gallat,
I.R.Greig,
J.H.Kim,
S.Wakatsuki,
L.M.Chavas,
S.G.Withers.
Tuning Mechanism-Based Inactivators of Neuraminidases: Mechanistic and Structural Insights. Angew.Chem.Int.Ed.Engl. V. 53 3382 2014.
Page generated: Thu Aug 1 04:10:30 2024
ISSN: ISSN 1433-7851 PubMed: 24591206 DOI: 10.1002/ANIE.201309675 |
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