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Atomistry » Fluorine » PDB 4olm-4pa0 » 4opx » |
Fluorine in PDB 4opx: Structure of Human Parp-1 Bound to A Dna Double Strand Break in Complex with (2R)-5-Fluoro-2-Methyl-2,3-Dihydro-1-Benzofuran-7- CarboxamideEnzymatic activity of Structure of Human Parp-1 Bound to A Dna Double Strand Break in Complex with (2R)-5-Fluoro-2-Methyl-2,3-Dihydro-1-Benzofuran-7- Carboxamide
All present enzymatic activity of Structure of Human Parp-1 Bound to A Dna Double Strand Break in Complex with (2R)-5-Fluoro-2-Methyl-2,3-Dihydro-1-Benzofuran-7- Carboxamide:
2.4.2.30; Protein crystallography data
The structure of Structure of Human Parp-1 Bound to A Dna Double Strand Break in Complex with (2R)-5-Fluoro-2-Methyl-2,3-Dihydro-1-Benzofuran-7- Carboxamide, PDB code: 4opx
was solved by
J.M.Pascal,
J.D.Steffen,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4opx:
The structure of Structure of Human Parp-1 Bound to A Dna Double Strand Break in Complex with (2R)-5-Fluoro-2-Methyl-2,3-Dihydro-1-Benzofuran-7- Carboxamide also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Human Parp-1 Bound to A Dna Double Strand Break in Complex with (2R)-5-Fluoro-2-Methyl-2,3-Dihydro-1-Benzofuran-7- Carboxamide
(pdb code 4opx). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of Human Parp-1 Bound to A Dna Double Strand Break in Complex with (2R)-5-Fluoro-2-Methyl-2,3-Dihydro-1-Benzofuran-7- Carboxamide, PDB code: 4opx: Fluorine binding site 1 out of 1 in 4opxGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Structure of Human Parp-1 Bound to A Dna Double Strand Break in Complex with (2R)-5-Fluoro-2-Methyl-2,3-Dihydro-1-Benzofuran-7- Carboxamide
![]() Mono view ![]() Stereo pair view
Reference:
M.R.Patel,
A.Bhatt,
J.D.Steffen,
A.Chergui,
J.Murai,
Y.Pommier,
J.M.Pascal,
L.D.Trombetta,
F.R.Fronczek,
T.T.Talele.
Discovery and Structure-Activity Relationship of Novel 2,3-Dihydrobenzofuran-7-Carboxamide and 2,3-Dihydrobenzofuran-3(2H)-One-7-Carboxamide Derivatives As Poly(Adp-Ribose)Polymerase-1 Inhibitors. J.Med.Chem. V. 57 5579 2014.
Page generated: Mon Jul 14 23:57:08 2025
ISSN: ISSN 0022-2623 PubMed: 24922587 DOI: 10.1021/JM5002502 |
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