Fluorine in PDB 4u21: GLUA2FLIP Slbd Complexed with Fw and (R,R)-2B Crystal Form E

The structure of GLUA2FLIP Slbd Complexed with Fw and (R,R)-2B Crystal Form E, PDB code: 4u21 was solved by L.Chen, E.Gouaux, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.15 / 1.39
Space group	P 21 21 2
Cell size a, b, c (Å), α, β, γ (°)	97.290, 121.320, 47.740, 90.00, 90.00, 90.00
R / Rfree (%)	18.3 / 19.8

The binding sites of Fluorine atom in the GLUA2FLIP Slbd Complexed with Fw and (R,R)-2B Crystal Form E (pdb code 4u21). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the GLUA2FLIP Slbd Complexed with Fw and (R,R)-2B Crystal Form E, PDB code: 4u21:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the GLUA2FLIP Slbd Complexed with Fw and (R,R)-2B Crystal Form E


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of GLUA2FLIP Slbd Complexed with Fw and (R,R)-2B Crystal Form E within 5.0Å range: probe atom residue distance (Å) B Occ A:F401 b:11.7 occ:1.00 F5 A:FWD401 0.0 11.7 1.0 C5 A:FWD401 1.3 10.2 1.0 C6 A:FWD401 2.4 10.9 1.0 C4 A:FWD401 2.4 11.7 1.0 O4 A:FWD401 2.7 10.6 1.0 CE A:MET196 3.0 8.2 1.0 O A:HOH623 3.1 11.7 1.0 OG1 A:THR174 3.3 6.9 1.0 SD A:MET196 3.4 8.3 1.0 CG A:MET196 3.5 7.9 1.0 N1 A:FWD401 3.6 7.6 1.0 N3 A:FWD401 3.7 7.4 1.0 OE1 A:GLU13 3.8 11.4 1.0 C2 A:FWD401 4.1 7.3 1.0 OE1 A:GLU193 4.1 6.3 1.0 CD A:GLU13 4.2 9.0 1.0 CB A:MET196 4.2 7.6 1.0 OE2 A:GLU13 4.3 9.8 1.0 CB A:THR174 4.5 7.9 1.0 N A:GLU193 4.6 5.7 1.0 CG2 A:THR174 4.6 8.5 1.0 CB A:GLU193 4.6 7.0 1.0 CD2 A:LEU138 4.7 11.3 1.0 CD A:GLU193 4.7 6.7 1.0 OH A:TYR61 4.7 9.7 1.0 CG A:GLU193 4.8 5.9 1.0 C7 A:FWD401 4.8 7.3 1.0 CB A:LEU192 4.9 5.8 1.0

Fluorine binding site 2 out of 2 in the GLUA2FLIP Slbd Complexed with Fw and (R,R)-2B Crystal Form E


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of GLUA2FLIP Slbd Complexed with Fw and (R,R)-2B Crystal Form E within 5.0Å range: probe atom residue distance (Å) B Occ B:F401 b:17.6 occ:1.00 F5 B:FWD401 0.0 17.6 1.0 C5 B:FWD401 1.3 15.7 1.0 C6 B:FWD401 2.4 14.5 1.0 C4 B:FWD401 2.5 18.3 1.0 O4 B:FWD401 2.7 17.5 1.0 CE B:MET196 3.1 8.6 1.0 O B:HOH632 3.1 14.2 1.0 OG1 B:THR174 3.4 11.8 1.0 SD B:MET196 3.4 13.3 1.0 CG B:MET196 3.5 10.9 1.0 N1 B:FWD401 3.5 11.0 1.0 N3 B:FWD401 3.7 9.8 1.0 OE2 B:GLU13 4.1 9.6 1.0 C2 B:FWD401 4.1 8.0 1.0 OE1 B:GLU193 4.1 8.5 1.0 CB B:MET196 4.2 11.5 1.0 CD B:GLU13 4.2 9.7 1.0 OE1 B:GLU13 4.2 16.2 1.0 N B:GLU193 4.5 8.7 1.0 CB B:THR174 4.6 12.5 1.0 CB B:GLU193 4.6 8.7 1.0 CG2 B:THR174 4.6 12.9 1.0 OH B:TYR61 4.6 10.7 1.0 CD B:GLU193 4.7 9.0 1.0 C7 B:FWD401 4.7 8.3 1.0 CD2 B:LEU138 4.7 10.3 1.0 CG B:GLU193 4.7 8.5 1.0 CB B:LEU192 4.9 8.6 1.0

K.L.Durr, L.Chen, R.A.Stein, R.De Zorzi, I.M.Folea, T.Walz, H.S.Mchaourab, E.Gouaux. Structure and Dynamics of Ampa Receptor GLUA2 in Resting, Pre-Open, and Desensitized States. Cell V. 158 778 2014.
ISSN: ISSN 1097-4172
PubMed: 25109876
DOI: 10.1016/J.CELL.2014.07.023