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Atomistry » Fluorine » PDB 4rx0-4u7z » 4u7z | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 4rx0-4u7z » 4u7z » |
Fluorine in PDB 4u7z: Mitogen-Activated Protein Kinase Kinase (MEK1) Bound to G805Enzymatic activity of Mitogen-Activated Protein Kinase Kinase (MEK1) Bound to G805
All present enzymatic activity of Mitogen-Activated Protein Kinase Kinase (MEK1) Bound to G805:
2.7.12.2; Protein crystallography data
The structure of Mitogen-Activated Protein Kinase Kinase (MEK1) Bound to G805, PDB code: 4u7z
was solved by
K.D.Robarge,
M.H.Ultsch,
C.Wiesmann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4u7z:
The structure of Mitogen-Activated Protein Kinase Kinase (MEK1) Bound to G805 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Mitogen-Activated Protein Kinase Kinase (MEK1) Bound to G805
(pdb code 4u7z). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Mitogen-Activated Protein Kinase Kinase (MEK1) Bound to G805, PDB code: 4u7z: Fluorine binding site 1 out of 1 in 4u7zGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Mitogen-Activated Protein Kinase Kinase (MEK1) Bound to G805
![]() Mono view ![]() Stereo pair view
Reference:
K.D.Robarge,
W.Lee,
C.Eigenbrot,
M.Ultsch,
C.Wiesmann,
R.Heald,
S.Price,
J.Hewitt,
P.Jackson,
P.Savy,
B.Burton,
E.F.Choo,
J.Pang,
J.Boggs,
A.Yang,
X.Yang,
M.Baumgardner.
Structure Based Design of Novel 6,5 Heterobicyclic Mitogen-Activated Protein Kinase Kinase (Mek) Inhibitors Leading to the Discovery of Imidazo[1,5-A] Pyrazine G-479. Bioorg.Med.Chem.Lett. V. 24 4714 2014.
Page generated: Thu Aug 1 05:53:23 2024
ISSN: ESSN 1464-3405 PubMed: 25193232 DOI: 10.1016/J.BMCL.2014.08.008 |
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