Fluorine »
PDB 4xyf-4ymo »
4y11 »
Fluorine in PDB 4y11: Trypsin in Complex with with Bpti Mutant (2S)-2-Amino-4,4,4- Trifluorobutanoic Acid
Enzymatic activity of Trypsin in Complex with with Bpti Mutant (2S)-2-Amino-4,4,4- Trifluorobutanoic Acid
All present enzymatic activity of Trypsin in Complex with with Bpti Mutant (2S)-2-Amino-4,4,4- Trifluorobutanoic Acid:
3.4.21.4;
3.4.21.4;
Protein crystallography data
The structure of Trypsin in Complex with with Bpti Mutant (2S)-2-Amino-4,4,4- Trifluorobutanoic Acid, PDB code: 4y11
was solved by
B.Loll,
S.Ye,
A.A.Berger,
U.Muelow,
C.Alings,
M.C.Wahl,
B.Koksch,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 36.10 / 1.30 |
| Space group | I 2 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 74.971, 82.102, 123.578, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 13.4 / 15.6 |
Other elements in 4y11:
The structure of Trypsin in Complex with with Bpti Mutant (2S)-2-Amino-4,4,4- Trifluorobutanoic Acid also contains other interesting chemical elements:
| Calcium | (Ca) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Trypsin in Complex with with Bpti Mutant (2S)-2-Amino-4,4,4- Trifluorobutanoic Acid
(pdb code 4y11). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Trypsin in Complex with with Bpti Mutant (2S)-2-Amino-4,4,4- Trifluorobutanoic Acid, PDB code: 4y11:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Trypsin in Complex with with Bpti Mutant (2S)-2-Amino-4,4,4- Trifluorobutanoic Acid, PDB code: 4y11:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 4y11
Go back to
Fluorine Binding Sites List in 4y11
Fluorine binding site 1 out
of 3 in the Trypsin in Complex with with Bpti Mutant (2S)-2-Amino-4,4,4- Trifluorobutanoic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Trypsin in Complex with with Bpti Mutant (2S)-2-Amino-4,4,4- Trifluorobutanoic Acid within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 4y11
Go back to
Fluorine Binding Sites List in 4y11
Fluorine binding site 2 out
of 3 in the Trypsin in Complex with with Bpti Mutant (2S)-2-Amino-4,4,4- Trifluorobutanoic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Trypsin in Complex with with Bpti Mutant (2S)-2-Amino-4,4,4- Trifluorobutanoic Acid within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 4y11
Go back to
Fluorine Binding Sites List in 4y11
Fluorine binding site 3 out
of 3 in the Trypsin in Complex with with Bpti Mutant (2S)-2-Amino-4,4,4- Trifluorobutanoic Acid
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Trypsin in Complex with with Bpti Mutant (2S)-2-Amino-4,4,4- Trifluorobutanoic Acid within 5.0Å range:
|
Reference:
S.Ye,
B.Loll,
A.A.Berger,
U.Mulow,
C.Alings,
M.C.Wahl,
B.Koksch.
Fluorine Teams Up with Water to Restore Inhibitor Activity to Mutant Bpti. Chem Sci V. 6 5246 2015.
ISSN: ISSN 2041-6520
PubMed: 29449928
DOI: 10.1039/C4SC03227F
Page generated: Tue Jul 15 01:36:07 2025
ISSN: ISSN 2041-6520
PubMed: 29449928
DOI: 10.1039/C4SC03227F
Last articles
Fe in 2YXOFe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
