Fluorine in PDB 4yjv: The Kinase Domain of Human Spleen Tyrosine (Syk) in Complex with GTC000250

All present enzymatic activity of The Kinase Domain of Human Spleen Tyrosine (Syk) in Complex with GTC000250:
2.7.10.2;

The structure of The Kinase Domain of Human Spleen Tyrosine (Syk) in Complex with GTC000250, PDB code: 4yjv was solved by D.O.Somers, M.Neu, J.Stuckey, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	27.59 / 1.65
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	39.460, 86.940, 40.430, 90.00, 92.59, 90.00
R / Rfree (%)	17.5 / 22.2

The binding sites of Fluorine atom in the The Kinase Domain of Human Spleen Tyrosine (Syk) in Complex with GTC000250 (pdb code 4yjv). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the The Kinase Domain of Human Spleen Tyrosine (Syk) in Complex with GTC000250, PDB code: 4yjv:

Fluorine binding site 1 out of 1 in the The Kinase Domain of Human Spleen Tyrosine (Syk) in Complex with GTC000250


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of The Kinase Domain of Human Spleen Tyrosine (Syk) in Complex with GTC000250 within 5.0Å range: probe atom residue distance (Å) B Occ A:F701 b:15.2 occ:1.00 F1 A:4DT701 0.0 15.2 1.0 C23 A:4DT701 1.3 14.6 1.0 C22 A:4DT701 2.3 13.9 1.0 C10 A:4DT701 2.4 14.2 1.0 H24 A:4DT701 2.6 13.8 0.0 C3 A:4DT701 2.8 15.9 1.0 N1 A:4DT701 2.9 16.5 1.0 CB A:MET448 3.1 16.1 1.0 C4 A:4DT701 3.2 16.0 1.0 CG A:MET448 3.3 21.2 1.0 C9 A:4DT701 3.3 18.5 1.0 H6 A:4DT701 3.5 15.9 0.0 CG1 A:VAL433 3.5 18.0 1.0 N8 A:4DT701 3.6 15.3 1.0 N4 A:4DT701 3.6 14.8 1.0 C8 A:4DT701 3.9 24.8 1.0 O A:HOH1066 3.9 27.5 1.0 C5 A:4DT701 4.0 17.7 1.0 C7 A:4DT701 4.0 18.6 1.0 C11 A:4DT701 4.0 14.1 1.0 H10 A:4DT701 4.1 24.7 0.0 CD1 A:LEU501 4.1 15.4 1.0 C6 A:4DT701 4.3 16.4 1.0 C2 A:4DT701 4.4 19.0 1.0 CE A:MET448 4.4 20.6 1.0 O A:GLU449 4.4 15.0 1.0 CB A:ALA400 4.4 13.7 1.0 CB A:VAL433 4.5 16.1 1.0 CG2 A:VAL433 4.6 15.7 1.0 CA A:MET448 4.6 13.6 1.0 H7 A:4DT701 4.6 17.6 0.0 SD A:MET448 4.7 26.8 1.0 N3 A:4DT701 4.8 27.2 1.0 N2 A:4DT701 4.8 25.3 1.0 H__2 A:4DT701 4.9 21.9 0.0 H__3 A:4DT701 4.9 21.9 0.0 H__4 A:4DT701 4.9 19.0 0.0 H__5 A:4DT701 4.9 19.0 0.0 O A:ALA400 4.9 15.8 1.0 C1 A:4DT701 5.0 21.9 1.0 C A:MET448 5.0 14.5 1.0 CB A:SER511 5.0 14.1 1.0

D.O.Somers, M.Neu, J.Stuckey. The Kinase Domain of Human Spleen Tyrosine (Syk) in Complex with GTC000250 To Be Published.