Atomistry » Fluorine » PDB 5esf-5fct » 5fck
Atomistry »
  Fluorine »
    PDB 5esf-5fct »
      5fck »

Fluorine in PDB 5fck: Complement Factor D in Complex with Compound 5

Enzymatic activity of Complement Factor D in Complex with Compound 5

All present enzymatic activity of Complement Factor D in Complex with Compound 5:
3.4.21.46;

Protein crystallography data

The structure of Complement Factor D in Complex with Compound 5, PDB code: 5fck was solved by A.Mac Sweeney, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 22.87 / 1.86
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 38.266, 48.742, 54.730, 90.00, 108.82, 90.00
R / Rfree (%) 18.7 / 23.7

Other elements in 5fck:

The structure of Complement Factor D in Complex with Compound 5 also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Complement Factor D in Complex with Compound 5 (pdb code 5fck). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Complement Factor D in Complex with Compound 5, PDB code: 5fck:

Fluorine binding site 1 out of 1 in 5fck

Go back to Fluorine Binding Sites List in 5fck
Fluorine binding site 1 out of 1 in the Complement Factor D in Complex with Compound 5


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Complement Factor D in Complex with Compound 5 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F301

b:13.3
occ:1.00
F A:5WC301 0.0 13.3 1.0
C27 A:5WC301 1.3 13.5 1.0
C28 A:5WC301 2.3 15.0 1.0
C11 A:5WC301 2.4 14.0 1.0
CL A:5WC301 2.8 17.7 1.0
C9 A:5WC301 2.8 12.8 1.0
N7 A:5WC301 2.9 13.2 1.0
C10 A:5WC301 3.1 12.9 1.0
CA A:GLY193 3.3 13.4 1.0
O A:LEU41 3.4 11.8 1.0
CD2 A:HIS40 3.5 14.3 1.0
O A:HIS40 3.5 11.4 1.0
C29 A:5WC301 3.6 13.7 1.0
C31 A:5WC301 3.6 13.9 1.0
C A:LEU41 4.0 12.6 1.0
C6 A:5WC301 4.0 13.6 1.0
C30 A:5WC301 4.1 15.1 1.0
N A:GLY193 4.1 12.8 1.0
CA A:LEU41 4.2 13.0 1.0
NE2 A:HIS40 4.2 13.3 1.0
C A:HIS40 4.2 11.9 1.0
CG A:HIS40 4.5 13.4 1.0
N A:LEU41 4.5 13.3 1.0
C A:GLY193 4.5 13.9 1.0
O A:GLY193 4.6 13.9 1.0
C5 A:5WC301 4.7 14.7 1.0
O8 A:5WC301 4.7 13.5 1.0
C A:LYS192 4.8 13.4 1.0
N A:CYS42 4.9 12.1 1.0
O A:LYS192 4.9 12.9 1.0
CB A:HIS40 5.0 13.3 1.0

Reference:

J.Maibaum, S.M.Liao, A.Vulpetti, N.Ostermann, S.Randl, S.Rudisser, E.Lorthiois, P.Erbel, B.Kinzel, F.A.Kolb, S.Barbieri, J.Wagner, C.Durand, K.Fettis, S.Dussauge, N.Hughes, O.Delgado, U.Hommel, T.Gould, A.Mac Sweeney, B.Gerhartz, F.Cumin, S.Flohr, A.Schubart, B.Jaffee, R.Harrison, A.M.Risitano, J.Eder, K.Anderson. Small-Molecule Factor D Inhibitors Targeting the Alternative Complement Pathway. Nat.Chem.Biol. V. 12 1105 2016.
ISSN: ESSN 1552-4469
PubMed: 27775713
DOI: 10.1038/NCHEMBIO.2208
Page generated: Tue Jul 15 03:29:20 2025

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy