Atomistry » Fluorine » PDB 5fd2-5g3j » 5fdx
Atomistry »
  Fluorine »
    PDB 5fd2-5g3j »
      5fdx »

Fluorine in PDB 5fdx: Structure of DDR1 Receptor Tyrosine Kinase in Complex with D2164 Inhibitor at 2.65 Angstroms Resolution.

Enzymatic activity of Structure of DDR1 Receptor Tyrosine Kinase in Complex with D2164 Inhibitor at 2.65 Angstroms Resolution.

All present enzymatic activity of Structure of DDR1 Receptor Tyrosine Kinase in Complex with D2164 Inhibitor at 2.65 Angstroms Resolution.:
2.7.10.1;

Protein crystallography data

The structure of Structure of DDR1 Receptor Tyrosine Kinase in Complex with D2164 Inhibitor at 2.65 Angstroms Resolution., PDB code: 5fdx was solved by S.G.Bartual, D.M.Pinkas, Z.Wang, K.Ding, P.Mahajan, K.Kupinska, S.Mukhopadhyay, C.Strain-Damerell, R.Chalk, O.Borkowska, R.Talon, J.Kopec, E.Williams, C.Tallant, A.Chaikuad, F.Sorell, J.Newman, N.Burgess-Brown, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, C.Bountra, A.Bullock, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.44 / 2.65
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 45.548, 120.340, 63.020, 90.00, 94.87, 90.00
R / Rfree (%) 19.4 / 27.3

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Structure of DDR1 Receptor Tyrosine Kinase in Complex with D2164 Inhibitor at 2.65 Angstroms Resolution. (pdb code 5fdx). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Structure of DDR1 Receptor Tyrosine Kinase in Complex with D2164 Inhibitor at 2.65 Angstroms Resolution., PDB code: 5fdx:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in 5fdx

Go back to Fluorine Binding Sites List in 5fdx
Fluorine binding site 1 out of 6 in the Structure of DDR1 Receptor Tyrosine Kinase in Complex with D2164 Inhibitor at 2.65 Angstroms Resolution.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of DDR1 Receptor Tyrosine Kinase in Complex with D2164 Inhibitor at 2.65 Angstroms Resolution. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1001

b:41.0
occ:1.00
F01 A:5X11001 0.0 41.0 1.0
CAA A:5X11001 1.3 37.1 1.0
F03 A:5X11001 2.2 35.5 1.0
F02 A:5X11001 2.2 36.5 1.0
CAY A:5X11001 2.3 35.0 1.0
CAK A:5X11001 2.8 33.2 1.0
CD1 A:LEU679 3.1 52.9 1.0
CG2 A:ILE684 3.5 44.3 1.0
CAJ A:5X11001 3.6 37.4 1.0
O A:ILE782 3.9 43.1 1.0
CG2 A:ILE685 4.0 39.0 1.0
CBB A:5X11001 4.2 37.3 1.0
CG A:LEU679 4.4 54.3 1.0
CAZ A:5X11001 4.6 37.2 1.0
CB A:LEU679 4.7 50.3 1.0
CA A:ALA783 4.8 40.5 1.0
C A:ILE782 4.8 42.8 1.0
C A:ALA783 4.8 41.5 1.0
O A:ALA783 4.9 40.6 1.0
CD1 A:LEU757 4.9 41.7 1.0
CD2 A:LEU757 4.9 43.0 1.0
CAL A:5X11001 4.9 38.1 1.0
CB A:ILE684 4.9 47.1 1.0

Fluorine binding site 2 out of 6 in 5fdx

Go back to Fluorine Binding Sites List in 5fdx
Fluorine binding site 2 out of 6 in the Structure of DDR1 Receptor Tyrosine Kinase in Complex with D2164 Inhibitor at 2.65 Angstroms Resolution.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structure of DDR1 Receptor Tyrosine Kinase in Complex with D2164 Inhibitor at 2.65 Angstroms Resolution. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1001

b:36.5
occ:1.00
F02 A:5X11001 0.0 36.5 1.0
CAA A:5X11001 1.3 37.1 1.0
F03 A:5X11001 2.2 35.5 1.0
F01 A:5X11001 2.2 41.0 1.0
CAY A:5X11001 2.4 35.0 1.0
O A:ALA783 3.1 40.6 1.0
NE2 A:HIS764 3.2 36.0 1.0
CAK A:5X11001 3.2 33.2 1.0
CD2 A:HIS764 3.2 36.7 1.0
CAJ A:5X11001 3.3 37.4 1.0
C A:ALA783 3.6 41.5 1.0
CB A:ASP784 4.0 38.9 1.0
CG2 A:ILE782 4.1 33.4 1.0
CA A:ALA783 4.1 40.5 1.0
O A:ILE782 4.2 43.1 1.0
N A:ASP784 4.2 37.3 1.0
CBB A:5X11001 4.4 37.3 1.0
CE1 A:HIS764 4.4 35.4 1.0
CG A:HIS764 4.4 34.5 1.0
N A:ALA783 4.4 40.9 1.0
C A:ILE782 4.5 42.8 1.0
CAZ A:5X11001 4.6 37.2 1.0
CD1 A:LEU757 4.7 41.7 1.0
CA A:ASP784 4.7 37.6 1.0
CD1 A:LEU679 5.0 52.9 1.0

Fluorine binding site 3 out of 6 in 5fdx

Go back to Fluorine Binding Sites List in 5fdx
Fluorine binding site 3 out of 6 in the Structure of DDR1 Receptor Tyrosine Kinase in Complex with D2164 Inhibitor at 2.65 Angstroms Resolution.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Structure of DDR1 Receptor Tyrosine Kinase in Complex with D2164 Inhibitor at 2.65 Angstroms Resolution. within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F1001

b:35.5
occ:1.00
F03 A:5X11001 0.0 35.5 1.0
CAA A:5X11001 1.3 37.1 1.0
F02 A:5X11001 2.2 36.5 1.0
F01 A:5X11001 2.2 41.0 1.0
CAY A:5X11001 2.4 35.0 1.0
CAJ A:5X11001 2.8 37.4 1.0
CE1 A:PHE762 3.3 34.8 1.0
CD1 A:LEU679 3.4 52.9 1.0
CZ A:PHE762 3.6 34.2 1.0
CAK A:5X11001 3.6 33.2 1.0
CAZ A:5X11001 4.1 37.2 1.0
CD2 A:HIS764 4.2 36.7 1.0
CD1 A:LEU757 4.2 41.7 1.0
CD1 A:PHE762 4.3 35.4 1.0
CD2 A:LEU757 4.4 43.0 1.0
NE2 A:HIS764 4.7 36.0 1.0
CG A:LEU679 4.7 54.3 1.0
CE2 A:PHE762 4.8 38.1 1.0
CBB A:5X11001 4.8 37.3 1.0
CG A:LEU757 5.0 43.3 1.0
CAL A:5X11001 5.0 38.1 1.0
CD2 A:LEU679 5.0 56.7 1.0

Fluorine binding site 4 out of 6 in 5fdx

Go back to Fluorine Binding Sites List in 5fdx
Fluorine binding site 4 out of 6 in the Structure of DDR1 Receptor Tyrosine Kinase in Complex with D2164 Inhibitor at 2.65 Angstroms Resolution.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Structure of DDR1 Receptor Tyrosine Kinase in Complex with D2164 Inhibitor at 2.65 Angstroms Resolution. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1001

b:46.2
occ:1.00
F01 B:5X11001 0.0 46.2 1.0
CAA B:5X11001 1.3 44.0 1.0
F02 B:5X11001 2.2 42.4 1.0
F03 B:5X11001 2.2 45.2 1.0
CAY B:5X11001 2.3 41.3 1.0
CAK B:5X11001 2.8 41.8 1.0
CD1 B:LEU679 3.2 60.2 1.0
CAJ B:5X11001 3.6 41.7 1.0
CG2 B:ILE684 3.6 53.1 1.0
CG2 B:ILE685 3.9 53.0 1.0
CBB B:5X11001 4.2 45.4 1.0
O B:ILE782 4.3 53.6 1.0
CG B:LEU679 4.5 61.8 1.0
CA B:ALA783 4.7 48.7 1.0
CAZ B:5X11001 4.7 43.5 1.0
CD2 B:LEU757 4.8 54.8 1.0
C B:ILE782 4.8 52.8 1.0
CAL B:5X11001 4.9 45.5 1.0
CB B:LEU679 4.9 59.8 1.0
C B:ALA783 4.9 51.8 1.0
CB B:ILE684 5.0 54.8 1.0
CD2 B:HIS764 5.0 45.7 1.0
N B:ILE685 5.0 52.9 1.0

Fluorine binding site 5 out of 6 in 5fdx

Go back to Fluorine Binding Sites List in 5fdx
Fluorine binding site 5 out of 6 in the Structure of DDR1 Receptor Tyrosine Kinase in Complex with D2164 Inhibitor at 2.65 Angstroms Resolution.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Structure of DDR1 Receptor Tyrosine Kinase in Complex with D2164 Inhibitor at 2.65 Angstroms Resolution. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1001

b:42.4
occ:1.00
F02 B:5X11001 0.0 42.4 1.0
CAA B:5X11001 1.4 44.0 1.0
F03 B:5X11001 2.2 45.2 1.0
F01 B:5X11001 2.2 46.2 1.0
CAY B:5X11001 2.4 41.3 1.0
CAK B:5X11001 3.0 41.8 1.0
NE2 B:HIS764 3.1 45.5 1.0
CD2 B:HIS764 3.2 45.7 1.0
C B:ALA783 3.3 51.8 1.0
O B:ALA783 3.4 51.5 1.0
CAJ B:5X11001 3.4 41.7 1.0
CA B:ALA783 3.7 48.7 1.0
N B:ASP784 3.7 47.5 1.0
CB B:ASP784 3.8 46.7 1.0
N B:ALA783 4.0 48.5 1.0
CG2 B:ILE782 4.0 50.4 1.0
CBB B:5X11001 4.1 45.4 1.0
CE1 B:HIS764 4.3 44.4 1.0
C B:ILE782 4.3 52.8 1.0
O B:ILE782 4.4 53.6 1.0
CA B:ASP784 4.4 46.0 1.0
CG B:HIS764 4.4 43.5 1.0
CAZ B:5X11001 4.6 43.5 1.0
CG2 B:ILE685 4.9 53.0 1.0
CAL B:5X11001 4.9 45.5 1.0
CG B:ASP784 4.9 56.7 1.0
CB B:ILE782 4.9 51.4 1.0
OD2 B:ASP784 4.9 62.6 1.0
ND1 B:HIS764 5.0 44.4 1.0

Fluorine binding site 6 out of 6 in 5fdx

Go back to Fluorine Binding Sites List in 5fdx
Fluorine binding site 6 out of 6 in the Structure of DDR1 Receptor Tyrosine Kinase in Complex with D2164 Inhibitor at 2.65 Angstroms Resolution.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Structure of DDR1 Receptor Tyrosine Kinase in Complex with D2164 Inhibitor at 2.65 Angstroms Resolution. within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1001

b:45.2
occ:1.00
F03 B:5X11001 0.0 45.2 1.0
CAA B:5X11001 1.3 44.0 1.0
F02 B:5X11001 2.2 42.4 1.0
F01 B:5X11001 2.2 46.2 1.0
CAY B:5X11001 2.3 41.3 1.0
CAJ B:5X11001 2.7 41.7 1.0
CE2 B:PHE762 3.3 51.5 1.0
CAK B:5X11001 3.6 41.8 1.0
CD1 B:LEU679 3.7 60.2 1.0
CZ B:PHE762 3.8 49.8 1.0
CD2 B:HIS764 3.9 45.7 1.0
CAZ B:5X11001 4.2 43.5 1.0
NE2 B:HIS764 4.4 45.5 1.0
CD2 B:PHE762 4.4 49.8 1.0
CD2 B:LEU757 4.5 54.8 1.0
CD1 B:LEU757 4.5 49.9 1.0
CBB B:5X11001 4.7 45.4 1.0
CG B:HIS764 4.7 43.5 1.0
CB B:ASP784 4.8 46.7 1.0
CAL B:5X11001 4.9 45.5 1.0

Reference:

S.G.Bartual, K.Ding, Z.Wang, N.A.Bullock. Structure of DDR1 Receptor Tyrosine Kinase in Complex with D2164 Inhibitor at 2.65 Angstroms Resolution. To Be Published.
Page generated: Tue Jul 15 03:30:10 2025

Last articles

Na in 2R22
Na in 2R20
Na in 2R21
Na in 2QZ7
Na in 2QZI
Na in 2R1S
Na in 2R0W
Na in 2QXF
Na in 2QZ2
Na in 2QWP
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy