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Fluorine in PDB 5fi4: Discovery of Imidazo[1,2-A]-Pyridine Inhibitors of Pan-PI3 Kinases That Are Efficacious in A Mouse Xenograft Model
Enzymatic activity of Discovery of Imidazo[1,2-A]-Pyridine Inhibitors of Pan-PI3 Kinases That Are Efficacious in A Mouse Xenograft Model
All present enzymatic activity of Discovery of Imidazo[1,2-A]-Pyridine Inhibitors of Pan-PI3 Kinases That Are Efficacious in A Mouse Xenograft Model:
2.7.1.153; 2.7.11.1;
2.7.1.153; 2.7.11.1;
Protein crystallography data
The structure of Discovery of Imidazo[1,2-A]-Pyridine Inhibitors of Pan-PI3 Kinases That Are Efficacious in A Mouse Xenograft Model, PDB code: 5fi4
was solved by
R.A.Elling,
M.S.Knapp,
W.Han,
L.M.Daniel,
Y.Xy,
M.T.Burger,
Z.Ni,
A.Smith,
J.Lan,
T.Williams,
J.Verhagen,
K.Huh,
H.Merritt,
J.Chan,
S.Kaufman,
C.F.Voliva,
S.Pecchi,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 38.56 / 2.50 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 105.200, 105.320, 134.390, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 19.4 / 24.5 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Discovery of Imidazo[1,2-A]-Pyridine Inhibitors of Pan-PI3 Kinases That Are Efficacious in A Mouse Xenograft Model
(pdb code 5fi4). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Discovery of Imidazo[1,2-A]-Pyridine Inhibitors of Pan-PI3 Kinases That Are Efficacious in A Mouse Xenograft Model, PDB code: 5fi4:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Discovery of Imidazo[1,2-A]-Pyridine Inhibitors of Pan-PI3 Kinases That Are Efficacious in A Mouse Xenograft Model, PDB code: 5fi4:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 5fi4
Go back to
Fluorine Binding Sites List in 5fi4
Fluorine binding site 1 out
of 3 in the Discovery of Imidazo[1,2-A]-Pyridine Inhibitors of Pan-PI3 Kinases That Are Efficacious in A Mouse Xenograft Model
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Discovery of Imidazo[1,2-A]-Pyridine Inhibitors of Pan-PI3 Kinases That Are Efficacious in A Mouse Xenograft Model within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 5fi4
Go back to
Fluorine Binding Sites List in 5fi4
Fluorine binding site 2 out
of 3 in the Discovery of Imidazo[1,2-A]-Pyridine Inhibitors of Pan-PI3 Kinases That Are Efficacious in A Mouse Xenograft Model
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Discovery of Imidazo[1,2-A]-Pyridine Inhibitors of Pan-PI3 Kinases That Are Efficacious in A Mouse Xenograft Model within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 5fi4
Go back to
Fluorine Binding Sites List in 5fi4
Fluorine binding site 3 out
of 3 in the Discovery of Imidazo[1,2-A]-Pyridine Inhibitors of Pan-PI3 Kinases That Are Efficacious in A Mouse Xenograft Model
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Discovery of Imidazo[1,2-A]-Pyridine Inhibitors of Pan-PI3 Kinases That Are Efficacious in A Mouse Xenograft Model within 5.0Å range:
|
Reference:
W.Han,
D.L.Menezes,
Y.Xu,
M.S.Knapp,
R.Elling,
M.T.Burger,
Z.J.Ni,
A.Smith,
J.Lan,
T.E.Williams,
J.Verhagen,
K.Huh,
H.Merritt,
J.Chan,
S.Kaufman,
C.F.Voliva,
S.Pecchi.
Discovery of Imidazo[1,2-A]-Pyridine Inhibitors of Pan-PI3 Kinases That Are Efficacious in A Mouse Xenograft Model. Bioorg.Med.Chem.Lett. V. 26 742 2016.
ISSN: ESSN 1464-3405
PubMed: 26774655
DOI: 10.1016/J.BMCL.2016.01.003
Page generated: Tue Jul 15 03:32:25 2025
ISSN: ESSN 1464-3405
PubMed: 26774655
DOI: 10.1016/J.BMCL.2016.01.003
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