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Atomistry » Fluorine » PDB 5he2-5hu1 » 5hes | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 5he2-5hu1 » 5hes » |
Fluorine in PDB 5hes: Human Leucine Zipper- and Sterile Alpha Motif-Containing Kinase (Zak, Mlt, Hccs-4, Mrk, Azk, Mltk) in Complex with VemurafenibEnzymatic activity of Human Leucine Zipper- and Sterile Alpha Motif-Containing Kinase (Zak, Mlt, Hccs-4, Mrk, Azk, Mltk) in Complex with Vemurafenib
All present enzymatic activity of Human Leucine Zipper- and Sterile Alpha Motif-Containing Kinase (Zak, Mlt, Hccs-4, Mrk, Azk, Mltk) in Complex with Vemurafenib:
2.7.11.25; Protein crystallography data
The structure of Human Leucine Zipper- and Sterile Alpha Motif-Containing Kinase (Zak, Mlt, Hccs-4, Mrk, Azk, Mltk) in Complex with Vemurafenib, PDB code: 5hes
was solved by
S.Mathea,
E.Salah,
K.R.Abdul Azeez,
C.Tallant,
M.Szklarz,
A.Chaikuad,
B.Shrestha,
F.J.Sorrell,
J.M.Elkins,
L.Shrestha,
N.Burgess-Brown,
F.Vondelft,
C.H.Arrowsmith,
A.M.Edwards,
C.Bountra,
S.Knapp,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5hes:
The structure of Human Leucine Zipper- and Sterile Alpha Motif-Containing Kinase (Zak, Mlt, Hccs-4, Mrk, Azk, Mltk) in Complex with Vemurafenib also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Leucine Zipper- and Sterile Alpha Motif-Containing Kinase (Zak, Mlt, Hccs-4, Mrk, Azk, Mltk) in Complex with Vemurafenib
(pdb code 5hes). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Human Leucine Zipper- and Sterile Alpha Motif-Containing Kinase (Zak, Mlt, Hccs-4, Mrk, Azk, Mltk) in Complex with Vemurafenib, PDB code: 5hes: Jump to Fluorine binding site number: 1; 2; 3; 4; Fluorine binding site 1 out of 4 in 5hesGo back to![]() ![]()
Fluorine binding site 1 out
of 4 in the Human Leucine Zipper- and Sterile Alpha Motif-Containing Kinase (Zak, Mlt, Hccs-4, Mrk, Azk, Mltk) in Complex with Vemurafenib
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 4 in 5hesGo back to![]() ![]()
Fluorine binding site 2 out
of 4 in the Human Leucine Zipper- and Sterile Alpha Motif-Containing Kinase (Zak, Mlt, Hccs-4, Mrk, Azk, Mltk) in Complex with Vemurafenib
![]() Mono view ![]() Stereo pair view
Fluorine binding site 3 out of 4 in 5hesGo back to![]() ![]()
Fluorine binding site 3 out
of 4 in the Human Leucine Zipper- and Sterile Alpha Motif-Containing Kinase (Zak, Mlt, Hccs-4, Mrk, Azk, Mltk) in Complex with Vemurafenib
![]() Mono view ![]() Stereo pair view
Fluorine binding site 4 out of 4 in 5hesGo back to![]() ![]()
Fluorine binding site 4 out
of 4 in the Human Leucine Zipper- and Sterile Alpha Motif-Containing Kinase (Zak, Mlt, Hccs-4, Mrk, Azk, Mltk) in Complex with Vemurafenib
![]() Mono view ![]() Stereo pair view
Reference:
S.Mathea,
K.R.Abdul Azeez,
E.Salah,
C.Tallant,
F.Wolfreys,
R.Konietzny,
R.Fischer,
H.J.Lou,
P.E.Brennan,
G.Schnapp,
A.Pautsch,
B.M.Kessler,
B.E.Turk,
S.Knapp.
Structure of the Human Protein Kinase Zak in Complex with Vemurafenib. Acs Chem.Biol. V. 11 1595 2016.
Page generated: Tue Jul 15 03:50:43 2025
ISSN: ESSN 1554-8937 PubMed: 26999302 DOI: 10.1021/ACSCHEMBIO.6B00043 |
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