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Atomistry » Fluorine » PDB 5he2-5hu1 » 5hpb » |
Fluorine in PDB 5hpb: Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-DiamineEnzymatic activity of Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine
All present enzymatic activity of Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine:
1.5.1.3; Protein crystallography data
The structure of Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine, PDB code: 5hpb
was solved by
V.Cody,
A.Ganjee,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine
(pdb code 5hpb). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine, PDB code: 5hpb: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 5hpbGo back to![]() ![]()
Fluorine binding site 1 out
of 3 in the Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 3 in 5hpbGo back to![]() ![]()
Fluorine binding site 2 out
of 3 in the Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine
![]() Mono view ![]() Stereo pair view
Fluorine binding site 3 out of 3 in 5hpbGo back to![]() ![]()
Fluorine binding site 3 out
of 3 in the Human Dihydrofolate Reductase Complex with Nadph and 5-Methyl-6- (Phenylthio-4'Trifluoromethyl)Thieno[2,3-D]Pyrimidine-2,4-Diamine
![]() Mono view ![]() Stereo pair view
Reference:
V.Cody,
A.Gangjee.
Human Dihydrofolate Reductase Ternary Complex with A Series Offluorine Substituted 5-Methyl-6-Phenythio)Thieno[2,3-D]Pyrimidine-2,4-Diamines To Be Published.
Page generated: Tue Jul 15 03:57:38 2025
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