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Fluorine in PDB 5jmp: Structure of Plasmodium Falciparum Dxr in Complex with A Beta- Substituted Fosmidomycin Analogue, LC57 and Manganese
Enzymatic activity of Structure of Plasmodium Falciparum Dxr in Complex with A Beta- Substituted Fosmidomycin Analogue, LC57 and Manganese
All present enzymatic activity of Structure of Plasmodium Falciparum Dxr in Complex with A Beta- Substituted Fosmidomycin Analogue, LC57 and Manganese:
1.1.1.267;
1.1.1.267;
Protein crystallography data
The structure of Structure of Plasmodium Falciparum Dxr in Complex with A Beta- Substituted Fosmidomycin Analogue, LC57 and Manganese, PDB code: 5jmp
was solved by
S.Sooriyaarachchi,
T.Bergfors,
T.A.Jones,
S.L.Mowbray,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 35.00 / 1.70 |
| Space group | P 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 51.718, 56.580, 85.660, 104.13, 103.33, 100.12 |
| R / Rfree (%) | 17.8 / 20.8 |
Other elements in 5jmp:
The structure of Structure of Plasmodium Falciparum Dxr in Complex with A Beta- Substituted Fosmidomycin Analogue, LC57 and Manganese also contains other interesting chemical elements:
| Manganese | (Mn) | 2 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Plasmodium Falciparum Dxr in Complex with A Beta- Substituted Fosmidomycin Analogue, LC57 and Manganese
(pdb code 5jmp). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Structure of Plasmodium Falciparum Dxr in Complex with A Beta- Substituted Fosmidomycin Analogue, LC57 and Manganese, PDB code: 5jmp:
Jump to Fluorine binding site number: 1; 2;
In total 2 binding sites of Fluorine where determined in the Structure of Plasmodium Falciparum Dxr in Complex with A Beta- Substituted Fosmidomycin Analogue, LC57 and Manganese, PDB code: 5jmp:
Jump to Fluorine binding site number: 1; 2;
Fluorine binding site 1 out of 2 in 5jmp
Go back to
Fluorine Binding Sites List in 5jmp
Fluorine binding site 1 out
of 2 in the Structure of Plasmodium Falciparum Dxr in Complex with A Beta- Substituted Fosmidomycin Analogue, LC57 and Manganese
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Structure of Plasmodium Falciparum Dxr in Complex with A Beta- Substituted Fosmidomycin Analogue, LC57 and Manganese within 5.0Å range:
|
Fluorine binding site 2 out of 2 in 5jmp
Go back to
Fluorine Binding Sites List in 5jmp
Fluorine binding site 2 out
of 2 in the Structure of Plasmodium Falciparum Dxr in Complex with A Beta- Substituted Fosmidomycin Analogue, LC57 and Manganese
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Structure of Plasmodium Falciparum Dxr in Complex with A Beta- Substituted Fosmidomycin Analogue, LC57 and Manganese within 5.0Å range:
|
Reference:
S.Sooriyaarachchi,
R.Chofor,
M.D.Risseeuw,
T.Bergfors,
J.Pouyez,
C.S.Dowd,
L.Maes,
J.Wouters,
T.A.Jones,
S.Van Calenbergh,
S.L.Mowbray.
Targeting An Aromatic Hotspot in Plasmodium Falciparum 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase with Beta-Arylpropyl Analogues of Fosmidomycin. Chemmedchem V. 11 2024 2016.
ISSN: ESSN 1860-7187
PubMed: 27487410
DOI: 10.1002/CMDC.201600249
Page generated: Tue Jul 15 04:29:50 2025
ISSN: ESSN 1860-7187
PubMed: 27487410
DOI: 10.1002/CMDC.201600249
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