Atomistry » Fluorine » PDB 5jxy-5ko1 » 5k0m
Atomistry »
  Fluorine »
    PDB 5jxy-5ko1 »
      5k0m »

Fluorine in PDB 5k0m: Targeting the PRC2 Complex Through A Novel Protein-Protein Interaction Inhibitor of Eed

Protein crystallography data

The structure of Targeting the PRC2 Complex Through A Novel Protein-Protein Interaction Inhibitor of Eed, PDB code: 5k0m was solved by C.G.Jakob, L.J.Bigelow, H.Zhu, C.Sun, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 48.91 / 1.83
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 57.843, 84.911, 91.627, 90.00, 90.00, 90.00
R / Rfree (%) 13.3 / 18.5

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Targeting the PRC2 Complex Through A Novel Protein-Protein Interaction Inhibitor of Eed (pdb code 5k0m). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Targeting the PRC2 Complex Through A Novel Protein-Protein Interaction Inhibitor of Eed, PDB code: 5k0m:

Fluorine binding site 1 out of 1 in 5k0m

Go back to Fluorine Binding Sites List in 5k0m
Fluorine binding site 1 out of 1 in the Targeting the PRC2 Complex Through A Novel Protein-Protein Interaction Inhibitor of Eed


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Targeting the PRC2 Complex Through A Novel Protein-Protein Interaction Inhibitor of Eed within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F501

b:23.7
occ:1.00
F A:6PU501 0.0 23.7 1.0
C24 A:6PU501 1.3 17.4 1.0
C23 A:6PU501 2.3 15.2 1.0
C25 A:6PU501 2.3 16.7 1.0
C3 A:6PU501 3.0 17.7 1.0
C17 A:6PU501 3.1 17.9 1.0
CB A:ASN194 3.4 14.8 1.0
CD2 A:LEU240 3.4 16.9 1.0
O A:LEU240 3.5 15.5 1.0
N1 A:6PU501 3.5 18.7 1.0
C22 A:6PU501 3.6 14.9 1.0
C20 A:6PU501 3.6 15.8 1.0
NH2 A:ARG367 3.6 32.4 1.0
CG A:ASN194 3.7 14.9 1.0
CB A:LEU240 3.8 16.9 1.0
CA A:LEU240 3.8 15.9 1.0
C21 A:6PU501 4.1 15.6 1.0
C A:LEU240 4.1 15.8 1.0
OD1 A:ASN194 4.1 16.3 1.0
CG A:LEU240 4.2 17.4 1.0
O A:ASN194 4.3 14.6 1.0
ND2 A:ASN194 4.3 17.0 1.0
C18 A:6PU501 4.4 17.7 1.0
CA A:ASN194 4.4 14.9 1.0
CZ A:ARG367 4.4 26.8 1.0
CD1 A:TYR365 4.5 17.7 1.0
C2 A:6PU501 4.5 19.0 1.0
C A:ASN194 4.6 15.4 1.0
C1 A:6PU501 4.7 19.0 1.0
C19 A:6PU501 4.7 17.1 1.0
C4 A:6PU501 4.7 18.2 1.0
NH1 A:ARG367 4.8 29.2 1.0
CD1 A:LEU240 4.9 17.3 1.0

Reference:

Y.He, S.Selvaraju, M.L.Curtin, C.G.Jakob, H.Zhu, K.M.Comess, B.Shaw, J.The, E.Lima-Fernandes, M.M.Szewczyk, D.Cheng, K.L.Klinge, H.Q.Li, M.Pliushchev, M.A.Algire, D.Maag, J.Guo, J.Dietrich, S.C.Panchal, A.M.Petros, R.F.Sweis, M.Torrent, L.J.Bigelow, G.Senisterra, F.Li, S.Kennedy, Q.Wu, D.J.Osterling, D.J.Lindley, W.Gao, S.Galasinski, D.Barsyte-Lovejoy, M.Vedadi, F.G.Buchanan, C.H.Arrowsmith, G.G.Chiang, C.Sun, W.N.Pappano. The Eed Protein-Protein Interaction Inhibitor A-395 Inactivates the PRC2 Complex. Nat. Chem. Biol. V. 13 389 2017.
ISSN: ESSN 1552-4469
PubMed: 28135237
DOI: 10.1038/NCHEMBIO.2306
Page generated: Tue Jul 15 04:35:40 2025

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy