Fluorine »
PDB 5jwc-5knj »
5k0x »
Fluorine in PDB 5k0x: Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC2541
Enzymatic activity of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC2541
All present enzymatic activity of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC2541:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC2541, PDB code: 5k0x
was solved by
A.L.Mciver,
W.Zhang,
Q.Liu,
X.Jiang,
M.A.Stashko,
J.Nichols,
M.J.Miley,
J.Norris-Drouin,
M.Machius,
D.Deryckere,
E.Wood,
D.K.Graham,
H.S.Earp,
D.Kireev,
S.V.Frye,
X.Wang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 27.86 / 2.23 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 51.671, 91.599, 69.769, 90.00, 102.37, 90.00 |
| R / Rfree (%) | 18.5 / 23.9 |
Other elements in 5k0x:
The structure of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC2541 also contains other interesting chemical elements:
| Chlorine | (Cl) | 5 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC2541
(pdb code 5k0x). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC2541, PDB code: 5k0x:
Jump to Fluorine binding site number: 1; 2;
In total 2 binding sites of Fluorine where determined in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC2541, PDB code: 5k0x:
Jump to Fluorine binding site number: 1; 2;
Fluorine binding site 1 out of 2 in 5k0x
Go back to
Fluorine Binding Sites List in 5k0x
Fluorine binding site 1 out
of 2 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC2541
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC2541 within 5.0Å range:
|
Fluorine binding site 2 out of 2 in 5k0x
Go back to
Fluorine Binding Sites List in 5k0x
Fluorine binding site 2 out
of 2 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC2541
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Inhibitor UNC2541 within 5.0Å range:
|
Reference:
A.L.Mciver,
W.Zhang,
Q.Liu,
X.Jiang,
M.A.Stashko,
J.Nichols,
M.J.Miley,
J.Norris-Drouin,
M.Machius,
D.Deryckere,
E.Wood,
D.K.Graham,
H.S.Earp,
D.Kireev,
S.V.Frye,
X.Wang.
Discovery of Macrocyclic Pyrimidines As Mertk-Specific Inhibitors. Chemmedchem V. 12 207 2017.
ISSN: ESSN 1860-7187
PubMed: 28032464
DOI: 10.1002/CMDC.201600589
Page generated: Thu Aug 1 10:50:03 2024
ISSN: ESSN 1860-7187
PubMed: 28032464
DOI: 10.1002/CMDC.201600589
Last articles
Zn in 9MJ5Zn in 9HNW
Zn in 9G0L
Zn in 9FNE
Zn in 9DZN
Zn in 9E0I
Zn in 9D32
Zn in 9DAK
Zn in 8ZXC
Zn in 8ZUF
