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Atomistry » Fluorine » PDB 5jxy-5ko1 » 5k14 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 5jxy-5ko1 » 5k14 » |
Fluorine in PDB 5k14: Hiv-1 Reverse Transcriptase in Complex with A 2,6-Difluorophenyl Dapy AnalogEnzymatic activity of Hiv-1 Reverse Transcriptase in Complex with A 2,6-Difluorophenyl Dapy Analog
All present enzymatic activity of Hiv-1 Reverse Transcriptase in Complex with A 2,6-Difluorophenyl Dapy Analog:
2.7.7.49; Protein crystallography data
The structure of Hiv-1 Reverse Transcriptase in Complex with A 2,6-Difluorophenyl Dapy Analog, PDB code: 5k14
was solved by
E.B.Lansdon,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Hiv-1 Reverse Transcriptase in Complex with A 2,6-Difluorophenyl Dapy Analog
(pdb code 5k14). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Hiv-1 Reverse Transcriptase in Complex with A 2,6-Difluorophenyl Dapy Analog, PDB code: 5k14: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 5k14Go back to![]() ![]()
Fluorine binding site 1 out
of 2 in the Hiv-1 Reverse Transcriptase in Complex with A 2,6-Difluorophenyl Dapy Analog
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 2 in 5k14Go back to![]() ![]()
Fluorine binding site 2 out
of 2 in the Hiv-1 Reverse Transcriptase in Complex with A 2,6-Difluorophenyl Dapy Analog
![]() Mono view ![]() Stereo pair view
Reference:
P.Simon,
O.Baszczynski,
D.Saman,
G.Stepan,
E.Hu,
E.B.Lansdon,
P.Jansa,
Z.Janeba.
Novel (2,6-Difluorophenyl)(2-(Phenylamino)Pyrimidin-4-Yl) Methanones with Restricted Conformation As Potent Non-Nucleoside Reverse Transcriptase Inhibitors Against Hiv-1. Eur.J.Med.Chem. V. 122 185 2016.
Page generated: Tue Jul 15 04:35:54 2025
ISSN: ISSN 0223-5234 PubMed: 27371922 DOI: 10.1016/J.EJMECH.2016.06.026 |
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