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Atomistry » Fluorine » PDB 5jxy-5ko1 » 5k4j | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 5jxy-5ko1 » 5k4j » |
Fluorine in PDB 5k4j: Crystal Structure of CDK2 in Complex with Compound 22Enzymatic activity of Crystal Structure of CDK2 in Complex with Compound 22
All present enzymatic activity of Crystal Structure of CDK2 in Complex with Compound 22:
2.7.11.22; Protein crystallography data
The structure of Crystal Structure of CDK2 in Complex with Compound 22, PDB code: 5k4j
was solved by
J.Yin,
W.Wang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 5k4j:
The structure of Crystal Structure of CDK2 in Complex with Compound 22 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of CDK2 in Complex with Compound 22
(pdb code 5k4j). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of CDK2 in Complex with Compound 22, PDB code: 5k4j: Fluorine binding site 1 out of 1 in 5k4jGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Crystal Structure of CDK2 in Complex with Compound 22
![]() Mono view ![]() Stereo pair view
Reference:
J.F.Blake,
M.Burkard,
J.Chan,
H.Chen,
K.J.Chou,
D.Diaz,
D.A.Dudley,
J.J.Gaudino,
S.E.Gould,
J.Grina,
T.Hunsaker,
L.Liu,
M.Martinson,
D.Moreno,
L.Mueller,
C.Orr,
P.Pacheco,
A.Qin,
K.Rasor,
L.Ren,
K.Robarge,
S.Shahidi-Latham,
J.Stults,
F.Sullivan,
W.Wang,
J.Yin,
A.Zhou,
M.Belvin,
M.Merchant,
J.Moffat,
J.B.Schwarz.
Discovery of (S)-1-(1-(4-Chloro-3-Fluorophenyl)-2-Hydroxyethyl) -4-(2-((1-Methyl-1H-Pyrazol-5-Yl)Amino)Pyrimidin-4-Yl) Pyridin-2(1H)-One (Gdc-0994), An Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development. J.Med.Chem. V. 59 5650 2016.
Page generated: Tue Jul 15 04:38:51 2025
ISSN: ISSN 0022-2623 PubMed: 27227380 DOI: 10.1021/ACS.JMEDCHEM.6B00389 |
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