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Atomistry » Fluorine » PDB 5lck-5lz4 » 5lyy | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 5lck-5lz4 » 5lyy » |
Fluorine in PDB 5lyy: Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2Enzymatic activity of Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2
All present enzymatic activity of Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2:
3.1.1.47; Protein crystallography data
The structure of Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2, PDB code: 5lyy
was solved by
A.Woolford,
P.Day,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2
(pdb code 5lyy). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2, PDB code: 5lyy: Fluorine binding site 1 out of 1 in 5lyyGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Fragment-Based Inhibitors of Lipoprotein Associated Phospholipase A2
![]() Mono view ![]() Stereo pair view
Reference:
A.J.Woolford,
P.J.Day,
V.Beneton,
V.Berdini,
J.E.Coyle,
Y.Dudit,
P.Grondin,
P.Huet,
L.Y.Lee,
E.S.Manas,
R.L.Mcmenamin,
C.W.Murray,
L.W.Page,
V.K.Patel,
F.Potvain,
S.J.Rich,
Y.Sang,
D.O.Somers,
L.Trottet,
Z.Wan,
X.Zhang.
Fragment-Based Approach to the Development of An Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2). J. Med. Chem. V. 59 10738 2016.
Page generated: Thu Aug 1 11:33:21 2024
ISSN: ISSN 1520-4804 PubMed: 27933945 DOI: 10.1021/ACS.JMEDCHEM.6B01427 |
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