Fluorine in PDB 5nz0: Structure of Transcriptional Regulatory Repressor Protein - Ethr From Mycobacterium Tuberculosis in Complex with Linezolid

The structure of Structure of Transcriptional Regulatory Repressor Protein - Ethr From Mycobacterium Tuberculosis in Complex with Linezolid, PDB code: 5nz0 was solved by M.Blaszczyk, V.Mendes, P.O.Nikiforov, T.L.Blundell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	20.23 / 1.83
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	121.382, 121.382, 33.780, 90.00, 90.00, 90.00
R / Rfree (%)	18.4 / 22

The binding sites of Fluorine atom in the Structure of Transcriptional Regulatory Repressor Protein - Ethr From Mycobacterium Tuberculosis in Complex with Linezolid (pdb code 5nz0). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of Transcriptional Regulatory Repressor Protein - Ethr From Mycobacterium Tuberculosis in Complex with Linezolid, PDB code: 5nz0:

Fluorine binding site 1 out of 1 in the Structure of Transcriptional Regulatory Repressor Protein - Ethr From Mycobacterium Tuberculosis in Complex with Linezolid


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of Transcriptional Regulatory Repressor Protein - Ethr From Mycobacterium Tuberculosis in Complex with Linezolid within 5.0Å range: probe atom residue distance (Å) B Occ A:F301 b:56.4 occ:1.00 F18 A:ZLD301 0.0 56.4 1.0 C16 A:ZLD301 1.3 45.1 1.0 C17 A:ZLD301 2.3 43.0 1.0 C5 A:ZLD301 2.3 43.4 1.0 C24 A:ZLD301 2.6 43.2 1.0 N19 A:ZLD301 2.8 42.1 1.0 ND2 A:ASN179 3.1 24.1 1.0 CG1 A:ILE107 3.5 20.3 1.0 C3 A:ZLD301 3.5 42.3 1.0 CA A:ILE107 3.5 20.8 1.0 C2 A:ZLD301 3.6 47.3 1.0 CD2 A:PHE110 3.7 23.5 1.0 C23 A:ZLD301 3.8 42.5 1.0 CB A:ILE107 3.9 20.2 1.0 CZ2 A:TRP207 3.9 20.3 1.0 C1 A:ZLD301 4.0 46.2 1.0 CH2 A:TRP207 4.0 19.4 1.0 CG2 A:ILE107 4.0 19.0 1.0 C20 A:ZLD301 4.2 39.9 1.0 CE2 A:PHE110 4.2 24.8 1.0 N A:ILE107 4.3 20.1 1.0 CG A:ASN179 4.3 22.0 1.0 CG A:PHE110 4.4 24.3 1.0 O A:ILE107 4.5 21.3 1.0 O A:GLY106 4.5 21.5 1.0 C A:ILE107 4.5 20.6 1.0 CB A:PHE110 4.6 22.2 1.0 CB A:ASN179 4.7 16.9 1.0 N4 A:ZLD301 4.7 57.2 1.0 CE2 A:TRP207 4.7 19.8 1.0 C A:GLY106 4.7 22.3 1.0 CD1 A:ILE107 4.8 22.9 1.0 CZ3 A:TRP207 4.8 21.8 1.0 C6 A:ZLD301 4.9 60.8 1.0 O22 A:ZLD301 4.9 43.7 1.0

P.O.Nikiforov, M.Blaszczyk, V.Mendes, H.I.Boshoff, C.E.Barry, T.L.Blundell, C.Abell. The Antibiotics Linezolid and Sutezolid Are Ligands For Mycobacterium Tuberculosis Ethr To Be Published.