Fluorine in PDB 5o5f: Crystal Structure of the Human BRPF1 Bromodomain in Complex with BZ038

The structure of Crystal Structure of the Human BRPF1 Bromodomain in Complex with BZ038, PDB code: 5o5f was solved by J.Zhu, A.Caflisch, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	30.38 / 1.30
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	60.765, 60.765, 63.516, 90.00, 90.00, 120.00
R / Rfree (%)	17.5 / 18.8

The binding sites of Fluorine atom in the Crystal Structure of the Human BRPF1 Bromodomain in Complex with BZ038 (pdb code 5o5f). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of the Human BRPF1 Bromodomain in Complex with BZ038, PDB code: 5o5f:

Fluorine binding site 1 out of 1 in the Crystal Structure of the Human BRPF1 Bromodomain in Complex with BZ038


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of the Human BRPF1 Bromodomain in Complex with BZ038 within 5.0Å range: probe atom residue distance (Å) B Occ A:F801 b:36.1 occ:1.00 FAF A:9LT801 0.0 36.1 1.0 CAU A:9LT801 1.3 27.5 1.0 CAN A:9LT801 2.4 30.4 1.0 CAI A:9LT801 2.4 31.9 1.0 CAW A:9LT801 3.6 34.7 1.0 CAG A:9LT801 3.6 31.6 1.0 CAJ A:9LT801 4.1 33.5 1.0 O3 A:NO3803 4.5 28.9 1.0 CBC A:9LT801 4.8 30.7 1.0 O A:HOH932 4.9 36.0 1.0

J.Zhu, C.Zhou, A.Caflisch. Structure-Based Discovery of Selective BRPF1 Bromodomain Inhibitors. Eur J Med Chem V. 155 337 2018.
ISSN: ISSN 1768-3254
PubMed: 29902720
DOI: 10.1016/J.EJMECH.2018.05.037