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Atomistry » Fluorine » PDB 6c0u-6cr2 » 6c2i | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 6c0u-6cr2 » 6c2i » |
Fluorine in PDB 6c2i: Structure of Bace-1 (Beta-Secretase) in Complex with : N-(3-((1R,5S, 6R)-3-Amino-5-Methyl-2-Oxa-4-Azabicyclo[4.1.0]Hept-3-En-5-Yl)-4- Fluorophenyl)-5-Methoxypyrazine-2-CarboxamideEnzymatic activity of Structure of Bace-1 (Beta-Secretase) in Complex with : N-(3-((1R,5S, 6R)-3-Amino-5-Methyl-2-Oxa-4-Azabicyclo[4.1.0]Hept-3-En-5-Yl)-4- Fluorophenyl)-5-Methoxypyrazine-2-Carboxamide
All present enzymatic activity of Structure of Bace-1 (Beta-Secretase) in Complex with : N-(3-((1R,5S, 6R)-3-Amino-5-Methyl-2-Oxa-4-Azabicyclo[4.1.0]Hept-3-En-5-Yl)-4- Fluorophenyl)-5-Methoxypyrazine-2-Carboxamide:
3.4.23.46; Protein crystallography data
The structure of Structure of Bace-1 (Beta-Secretase) in Complex with : N-(3-((1R,5S, 6R)-3-Amino-5-Methyl-2-Oxa-4-Azabicyclo[4.1.0]Hept-3-En-5-Yl)-4- Fluorophenyl)-5-Methoxypyrazine-2-Carboxamide, PDB code: 6c2i
was solved by
E.A.Sickmier,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6c2i:
The structure of Structure of Bace-1 (Beta-Secretase) in Complex with : N-(3-((1R,5S, 6R)-3-Amino-5-Methyl-2-Oxa-4-Azabicyclo[4.1.0]Hept-3-En-5-Yl)-4- Fluorophenyl)-5-Methoxypyrazine-2-Carboxamide also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Bace-1 (Beta-Secretase) in Complex with : N-(3-((1R,5S, 6R)-3-Amino-5-Methyl-2-Oxa-4-Azabicyclo[4.1.0]Hept-3-En-5-Yl)-4- Fluorophenyl)-5-Methoxypyrazine-2-Carboxamide
(pdb code 6c2i). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of Bace-1 (Beta-Secretase) in Complex with : N-(3-((1R,5S, 6R)-3-Amino-5-Methyl-2-Oxa-4-Azabicyclo[4.1.0]Hept-3-En-5-Yl)-4- Fluorophenyl)-5-Methoxypyrazine-2-Carboxamide, PDB code: 6c2i: Fluorine binding site 1 out of 1 in 6c2iGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Structure of Bace-1 (Beta-Secretase) in Complex with : N-(3-((1R,5S, 6R)-3-Amino-5-Methyl-2-Oxa-4-Azabicyclo[4.1.0]Hept-3-En-5-Yl)-4- Fluorophenyl)-5-Methoxypyrazine-2-Carboxamide
![]() Mono view ![]() Stereo pair view
Reference:
J.D.Low,
M.D.Bartberger,
Y.Cheng,
D.Whittington,
Q.Xue,
S.Wood,
J.R.Allen,
A.E.Minatti.
Diastereoselective Synthesis of Fused Cyclopropyl-3-Amino-2,4-Oxazine Beta-Amyloid Cleaving Enzyme (Bace) Inhibitors and Their Biological Evaluation. Bioorg. Med. Chem. Lett. V. 28 1111 2018.
Page generated: Tue Jul 15 10:19:44 2025
ISSN: ESSN 1464-3405 PubMed: 29426770 DOI: 10.1016/J.BMCL.2018.01.056 |
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