Fluorine »
PDB 6eol-6fex »
6es0 »
Fluorine in PDB 6es0: Crystal Structure of the Kinase Domain of Human RIPK2 in Complex with the Activation Loop Targeting Inhibitor Cs-R35
Enzymatic activity of Crystal Structure of the Kinase Domain of Human RIPK2 in Complex with the Activation Loop Targeting Inhibitor Cs-R35
All present enzymatic activity of Crystal Structure of the Kinase Domain of Human RIPK2 in Complex with the Activation Loop Targeting Inhibitor Cs-R35:
2.7.10.2; 2.7.11.1;
2.7.10.2; 2.7.11.1;
Protein crystallography data
The structure of Crystal Structure of the Kinase Domain of Human RIPK2 in Complex with the Activation Loop Targeting Inhibitor Cs-R35, PDB code: 6es0
was solved by
D.M.Pinkas,
J.C.Bufton,
C.Suebsuwong,
S.S.Ray,
B.Dai,
J.A.Newman,
N.A.Burgess-Brown,
F.Von Delft,
C.H.Arrowsmith,
A.M.Edwards,
C.Bountra,
A.Degterev,
G.D.Cuny,
A.N.Bullock,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 71.74 / 2.38 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 61.980, 83.740, 139.100, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 21.4 / 25.8 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Kinase Domain of Human RIPK2 in Complex with the Activation Loop Targeting Inhibitor Cs-R35
(pdb code 6es0). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of the Kinase Domain of Human RIPK2 in Complex with the Activation Loop Targeting Inhibitor Cs-R35, PDB code: 6es0:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Crystal Structure of the Kinase Domain of Human RIPK2 in Complex with the Activation Loop Targeting Inhibitor Cs-R35, PDB code: 6es0:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 6es0
Go back to
Fluorine Binding Sites List in 6es0
Fluorine binding site 1 out
of 4 in the Crystal Structure of the Kinase Domain of Human RIPK2 in Complex with the Activation Loop Targeting Inhibitor Cs-R35
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of the Kinase Domain of Human RIPK2 in Complex with the Activation Loop Targeting Inhibitor Cs-R35 within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 6es0
Go back to
Fluorine Binding Sites List in 6es0
Fluorine binding site 2 out
of 4 in the Crystal Structure of the Kinase Domain of Human RIPK2 in Complex with the Activation Loop Targeting Inhibitor Cs-R35
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of the Kinase Domain of Human RIPK2 in Complex with the Activation Loop Targeting Inhibitor Cs-R35 within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 6es0
Go back to
Fluorine Binding Sites List in 6es0
Fluorine binding site 3 out
of 4 in the Crystal Structure of the Kinase Domain of Human RIPK2 in Complex with the Activation Loop Targeting Inhibitor Cs-R35
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of the Kinase Domain of Human RIPK2 in Complex with the Activation Loop Targeting Inhibitor Cs-R35 within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 6es0
Go back to
Fluorine Binding Sites List in 6es0
Fluorine binding site 4 out
of 4 in the Crystal Structure of the Kinase Domain of Human RIPK2 in Complex with the Activation Loop Targeting Inhibitor Cs-R35
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of the Kinase Domain of Human RIPK2 in Complex with the Activation Loop Targeting Inhibitor Cs-R35 within 5.0Å range:
|
Reference:
C.Suebsuwong,
D.M.Pinkas,
S.S.Ray,
J.C.Bufton,
B.Dai,
A.N.Bullock,
A.Degterev,
G.D.Cuny.
Activation Loop Targeting Strategy For Design of Receptor-Interacting Protein Kinase 2 (RIPK2) Inhibitors. Bioorg. Med. Chem. Lett. V. 28 577 2018.
ISSN: ESSN 1464-3405
PubMed: 29409752
DOI: 10.1016/J.BMCL.2018.01.044
Page generated: Tue Jul 15 11:17:28 2025
ISSN: ESSN 1464-3405
PubMed: 29409752
DOI: 10.1016/J.BMCL.2018.01.044
Last articles
Mg in 9G0QMg in 9G0P
Mg in 9FSF
Mg in 9G0O
Mg in 9FS8
Mg in 9G0F
Mg in 9G0D
Mg in 9G0C
Mg in 9G0A
Mg in 9G09
