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Fluorine in PDB 6et4: Human Dihydroorotate Dehydrogenase in Complex with Novel Inhibitor
Enzymatic activity of Human Dihydroorotate Dehydrogenase in Complex with Novel Inhibitor
All present enzymatic activity of Human Dihydroorotate Dehydrogenase in Complex with Novel Inhibitor:
1.3.5.2;
1.3.5.2;
Protein crystallography data
The structure of Human Dihydroorotate Dehydrogenase in Complex with Novel Inhibitor, PDB code: 6et4
was solved by
M.Hakansson,
B.Walse,
A.-L.Gustavsson,
S.Lain,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 30.00 / 1.70 |
| Space group | P 32 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 90.860, 90.860, 122.700, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 10.5 / 13.8 |
Other elements in 6et4:
The structure of Human Dihydroorotate Dehydrogenase in Complex with Novel Inhibitor also contains other interesting chemical elements:
| Chlorine | (Cl) | 3 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Dihydroorotate Dehydrogenase in Complex with Novel Inhibitor
(pdb code 6et4). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Human Dihydroorotate Dehydrogenase in Complex with Novel Inhibitor, PDB code: 6et4:
In total only one binding site of Fluorine was determined in the Human Dihydroorotate Dehydrogenase in Complex with Novel Inhibitor, PDB code: 6et4:
Fluorine binding site 1 out of 1 in 6et4
Go back to
Fluorine Binding Sites List in 6et4
Fluorine binding site 1 out
of 1 in the Human Dihydroorotate Dehydrogenase in Complex with Novel Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Human Dihydroorotate Dehydrogenase in Complex with Novel Inhibitor within 5.0Å range:
|
Reference:
M.J.G.W.Ladds,
I.M.M.Van Leeuwen,
C.J.Drummond,
S.Chu,
A.R.Healy,
G.Popova,
A.Pastor Fernandez,
T.Mollick,
S.Darekar,
S.K.Sedimbi,
M.Nekulova,
M.C.C.Sachweh,
J.Campbell,
M.Higgins,
C.Tuck,
M.Popa,
M.M.Safont,
P.Gelebart,
Z.Fandalyuk,
A.M.Thompson,
R.Svensson,
A.L.Gustavsson,
L.Johansson,
K.Farnegardh,
U.Yngve,
A.Saleh,
M.Haraldsson,
A.C.A.D'hollander,
M.Franco,
Y.Zhao,
M.Hakansson,
B.Walse,
K.Larsson,
E.M.Peat,
V.Pelechano,
J.Lunec,
B.Vojtesek,
M.Carmena,
W.C.Earnshaw,
A.R.Mccarthy,
N.J.Westwood,
M.Arsenian-Henriksson,
D.P.Lane,
R.Bhatia,
E.Mccormack,
S.Lain.
A Dhodh Inhibitor Increases P53 Synthesis and Enhances Tumor Cell Killing By P53 Degradation Blockage. Nat Commun V. 9 1107 2018.
ISSN: ESSN 2041-1723
PubMed: 29549331
DOI: 10.1038/S41467-018-03441-3
Page generated: Tue Jul 15 11:18:13 2025
ISSN: ESSN 2041-1723
PubMed: 29549331
DOI: 10.1038/S41467-018-03441-3
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