Fluorine »
PDB 6g0w-6gqm »
6gbx »
Fluorine in PDB 6gbx: Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177
Enzymatic activity of Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177
All present enzymatic activity of Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177:
2.3.2.5;
2.3.2.5;
Protein crystallography data
The structure of Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177, PDB code: 6gbx
was solved by
C.Pozzi,
F.Di Pisa,
M.Benvenuti,
S.Mangani,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 95.23 / 1.72 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 86.140, 149.810, 95.980, 90.00, 97.18, 90.00 |
| R / Rfree (%) | 15.8 / 18.3 |
Other elements in 6gbx:
The structure of Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177 also contains other interesting chemical elements:
| Zinc | (Zn) | 3 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177
(pdb code 6gbx). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177, PDB code: 6gbx:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177, PDB code: 6gbx:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 6gbx
Go back to
Fluorine Binding Sites List in 6gbx
Fluorine binding site 1 out
of 3 in the Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177 within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 6gbx
Go back to
Fluorine Binding Sites List in 6gbx
Fluorine binding site 2 out
of 3 in the Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177 within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 6gbx
Go back to
Fluorine Binding Sites List in 6gbx
Fluorine binding site 3 out
of 3 in the Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Human Glutaminyl Cyclase Variant Y115E-Y117E in Complex with SEN177 within 5.0Å range:
|
Reference:
C.Pozzi,
F.Di Pisa,
M.Benvenuti,
S.Mangani.
The Structure of the Human Glutaminyl Cyclase-SEN177 Complex Indicates Routes For Developing New Potent Inhibitors As Possible Agents For the Treatment of Neurological Disorders. J. Biol. Inorg. Chem. V. 23 1219 2018.
ISSN: ESSN 1432-1327
PubMed: 30132075
DOI: 10.1007/S00775-018-1605-1
Page generated: Tue Jul 15 11:49:53 2025
ISSN: ESSN 1432-1327
PubMed: 30132075
DOI: 10.1007/S00775-018-1605-1
Last articles
Fe in 2YXOFe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
