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Atomistry » Fluorine » PDB 6g0w-6gqm » 6gqm | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 6g0w-6gqm » 6gqm » |
Fluorine in PDB 6gqm: Crystal Structure of Human C-Kit Kinase Domain in Complex with A Small Molecule Inhibitor, AZD3229Enzymatic activity of Crystal Structure of Human C-Kit Kinase Domain in Complex with A Small Molecule Inhibitor, AZD3229
All present enzymatic activity of Crystal Structure of Human C-Kit Kinase Domain in Complex with A Small Molecule Inhibitor, AZD3229:
2.7.10.1; Protein crystallography data
The structure of Crystal Structure of Human C-Kit Kinase Domain in Complex with A Small Molecule Inhibitor, AZD3229, PDB code: 6gqm
was solved by
M.Schimpl,
C.J.Hardy,
D.J.Ogg,
R.C.Overman,
M.J.Packer,
J.G.Kettle,
R.Anjum,
E.Barry,
D.Bhavsar,
C.Brown,
A.Campbell,
K.Goldberg,
M.Grondine,
S.Guichard,
T.Hunt,
O.Jones,
X.Li,
O.Moleva,
S.Pearson,
W.Shao,
A.Smith,
J.Smith,
D.Stead,
S.Stokes,
M.Tucker,
Y.Ye,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6gqm:
The structure of Crystal Structure of Human C-Kit Kinase Domain in Complex with A Small Molecule Inhibitor, AZD3229 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human C-Kit Kinase Domain in Complex with A Small Molecule Inhibitor, AZD3229
(pdb code 6gqm). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Human C-Kit Kinase Domain in Complex with A Small Molecule Inhibitor, AZD3229, PDB code: 6gqm: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 6gqmGo back to![]() ![]()
Fluorine binding site 1 out
of 2 in the Crystal Structure of Human C-Kit Kinase Domain in Complex with A Small Molecule Inhibitor, AZD3229
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 2 in 6gqmGo back to![]() ![]()
Fluorine binding site 2 out
of 2 in the Crystal Structure of Human C-Kit Kinase Domain in Complex with A Small Molecule Inhibitor, AZD3229
![]() Mono view ![]() Stereo pair view
Reference:
J.G.Kettle,
R.Anjum,
E.Barry,
D.Bhavsar,
C.Brown,
S.Boyd,
A.Campbell,
K.Goldberg,
M.Grondine,
S.Guichard,
C.J.Hardy,
T.Hunt,
R.D.O.Jones,
X.Li,
O.Moleva,
D.Ogg,
R.C.Overman,
M.J.Packer,
S.Pearson,
M.Schimpl,
W.Shao,
A.Smith,
J.M.Smith,
D.Stead,
S.Stokes,
M.Tucker,
Y.Ye.
Discovery of N-(4-{[5-Fluoro-7-(2-Methoxyethoxy) Quinazolin-4-Yl]Amino}Phenyl)-2-[4-(Propan-2-Yl)-1 H-1,2,3-Triazol-1-Yl]Acetamide (AZD3229), A Potent Pan-Kit Mutant Inhibitor For the Treatment of Gastrointestinal Stromal Tumors. J. Med. Chem. V. 61 8797 2018.
Page generated: Tue Jul 15 11:58:03 2025
ISSN: ISSN 1520-4804 PubMed: 30204441 DOI: 10.1021/ACS.JMEDCHEM.8B00938 |
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