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Atomistry » Fluorine » PDB 6hcu-6hmp » 6hkn | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 6hcu-6hmp » 6hkn » |
Fluorine in PDB 6hkn: Crystal Structure of Compound 35 with ERK5Enzymatic activity of Crystal Structure of Compound 35 with ERK5
All present enzymatic activity of Crystal Structure of Compound 35 with ERK5:
2.7.11.24; Protein crystallography data
The structure of Crystal Structure of Compound 35 with ERK5, PDB code: 6hkn
was solved by
D.Nguyen,
C.Lemos,
L.Wortmann,
K.Eis,
S.J.Holton,
U.Boemer,
C.Lechner,
S.Prechtl,
D.Suelze,
F.Siegel,
F.Prinz,
R.Lesche,
B.Nicke,
D.Mumberg,
M.Bauser,
A.Haegebarth,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Compound 35 with ERK5
(pdb code 6hkn). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Crystal Structure of Compound 35 with ERK5, PDB code: 6hkn: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 6hknGo back to![]() ![]()
Fluorine binding site 1 out
of 3 in the Crystal Structure of Compound 35 with ERK5
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 3 in 6hknGo back to![]() ![]()
Fluorine binding site 2 out
of 3 in the Crystal Structure of Compound 35 with ERK5
![]() Mono view ![]() Stereo pair view
Fluorine binding site 3 out of 3 in 6hknGo back to![]() ![]()
Fluorine binding site 3 out
of 3 in the Crystal Structure of Compound 35 with ERK5
![]() Mono view ![]() Stereo pair view
Reference:
D.Nguyen,
C.Lemos,
L.Wortmann,
K.Eis,
S.J.Holton,
U.Boemer,
D.Moosmayer,
U.Eberspaecher,
J.Weiske,
C.Lechner,
S.Prechtl,
D.Suelzle,
F.Siegel,
F.Prinz,
R.Lesche,
B.Nicke,
K.Nowak-Reppel,
H.Himmel,
D.Mumberg,
F.Von Nussbaum,
C.F.Nising,
M.Bauser,
A.Haegebarth.
Discovery and Characterization of the Potent and Highly Selective (Piperidin-4-Yl)Pyrido[3,2- D]Pyrimidine Based in Vitro Probe Bay-885 For the Kinase ERK5. J. Med. Chem. V. 62 928 2019.
Page generated: Tue Jul 15 12:20:03 2025
ISSN: ISSN 1520-4804 PubMed: 30563338 DOI: 10.1021/ACS.JMEDCHEM.8B01606 |
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