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Fluorine in PDB 6luq: Haloperidol Bound D2 Dopamine Receptor Structure Inspired Discovery of Subtype Selective Ligands
Enzymatic activity of Haloperidol Bound D2 Dopamine Receptor Structure Inspired Discovery of Subtype Selective Ligands
All present enzymatic activity of Haloperidol Bound D2 Dopamine Receptor Structure Inspired Discovery of Subtype Selective Ligands:
3.2.1.17;
3.2.1.17;
Protein crystallography data
The structure of Haloperidol Bound D2 Dopamine Receptor Structure Inspired Discovery of Subtype Selective Ligands, PDB code: 6luq
was solved by
L.Fan,
L.Tan,
Z.Chen,
J.Qi,
F.Nie,
Z.Luo,
J.Cheng,
S.Wang,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 33.39 / 3.10 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 50.433, 72.820, 150.269, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 21.5 / 22.9 |
Other elements in 6luq:
The structure of Haloperidol Bound D2 Dopamine Receptor Structure Inspired Discovery of Subtype Selective Ligands also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Haloperidol Bound D2 Dopamine Receptor Structure Inspired Discovery of Subtype Selective Ligands
(pdb code 6luq). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Haloperidol Bound D2 Dopamine Receptor Structure Inspired Discovery of Subtype Selective Ligands, PDB code: 6luq:
In total only one binding site of Fluorine was determined in the Haloperidol Bound D2 Dopamine Receptor Structure Inspired Discovery of Subtype Selective Ligands, PDB code: 6luq:
Fluorine binding site 1 out of 1 in 6luq
Go back to
Fluorine Binding Sites List in 6luq
Fluorine binding site 1 out
of 1 in the Haloperidol Bound D2 Dopamine Receptor Structure Inspired Discovery of Subtype Selective Ligands
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Haloperidol Bound D2 Dopamine Receptor Structure Inspired Discovery of Subtype Selective Ligands within 5.0Å range:
|
Reference:
L.Fan,
L.Tan,
Z.Chen,
J.Qi,
F.Nie,
Z.Luo,
J.Cheng,
S.Wang.
Haloperidol Bound D2 Dopamine Receptor Structure Inspired the Discovery of Subtype Selective Ligands Nat Commun 2020.
ISSN: ESSN 2041-1723
Page generated: Thu Aug 1 22:08:22 2024
ISSN: ESSN 2041-1723
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