Fluorine in PDB 6lw1: Cryo-Em Structure of TLR7/Cpd-7 (Dsr-139970) Complex in Open Form

The binding sites of Fluorine atom in the Cryo-Em Structure of TLR7/Cpd-7 (Dsr-139970) Complex in Open Form (pdb code 6lw1). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Cryo-Em Structure of TLR7/Cpd-7 (Dsr-139970) Complex in Open Form, PDB code: 6lw1:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Cryo-Em Structure of TLR7/Cpd-7 (Dsr-139970) Complex in Open Form


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of TLR7/Cpd-7 (Dsr-139970) Complex in Open Form within 5.0Å range: probe atom residue distance (Å) B Occ A:F1001 b:17.0 occ:1.00 F A:EX31001 0.0 17.0 1.0 C17 A:EX31001 1.3 17.0 1.0 C15 A:EX31001 2.3 17.0 1.0 C18 A:EX31001 2.4 17.0 1.0 CE1 A:PHE349 3.5 15.5 1.0 C14 A:EX31001 3.6 17.0 1.0 N4 A:EX31001 3.6 17.0 1.0 CG2 A:THR406 3.7 17.5 1.0 O A:THR406 3.7 17.5 1.0 CD1 A:PHE349 3.8 15.5 1.0 CA A:GLY379 3.8 15.1 1.0 CG2 A:VAL381 3.9 16.1 1.0 CE1 A:PHE351 4.0 17.5 1.0 C16 A:EX31001 4.0 17.0 1.0 CE2 A:PHE408 4.4 14.2 1.0 CB A:THR406 4.5 17.5 1.0 CD1 A:PHE351 4.5 17.5 1.0 CZ A:PHE351 4.6 17.5 1.0 N A:GLY379 4.7 15.1 1.0 C4 A:EX31001 4.7 17.0 1.0 C A:GLY379 4.7 15.1 1.0 C A:THR406 4.7 17.5 1.0 CZ A:PHE349 4.8 15.5 1.0 O A:GLY379 4.8 15.1 1.0 C23 A:EX31001 4.9 17.0 1.0 N2 A:EX31001 5.0 17.0 1.0

Fluorine binding site 2 out of 2 in the Cryo-Em Structure of TLR7/Cpd-7 (Dsr-139970) Complex in Open Form


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of TLR7/Cpd-7 (Dsr-139970) Complex in Open Form within 5.0Å range: probe atom residue distance (Å) B Occ B:F1001 b:17.3 occ:1.00 F B:EX31001 0.0 17.3 1.0 C17 B:EX31001 1.3 17.3 1.0 C15 B:EX31001 2.3 17.3 1.0 C18 B:EX31001 2.4 17.3 1.0 CE1 B:PHE349 3.6 15.0 1.0 C14 B:EX31001 3.6 17.3 1.0 N4 B:EX31001 3.6 17.3 1.0 CG2 B:THR406 3.6 18.1 1.0 O B:THR406 3.7 18.1 1.0 CD1 B:PHE349 3.8 15.0 1.0 CA B:GLY379 3.8 15.7 1.0 CG2 B:VAL381 3.9 16.5 1.0 CE1 B:PHE351 4.0 17.6 1.0 C16 B:EX31001 4.0 17.3 1.0 CE2 B:PHE408 4.4 16.8 1.0 CB B:THR406 4.5 18.1 1.0 CD1 B:PHE351 4.5 17.6 1.0 CZ B:PHE351 4.6 17.6 1.0 N B:GLY379 4.7 15.7 1.0 C4 B:EX31001 4.7 17.3 1.0 C B:THR406 4.7 18.1 1.0 C B:GLY379 4.7 15.7 1.0 CZ B:PHE349 4.8 15.0 1.0 O B:GLY379 4.8 15.7 1.0 C23 B:EX31001 4.9 17.3 1.0 N2 B:EX31001 5.0 17.3 1.0

S.Tojo, Z.Zhang, H.Matsui, M.Tahara, M.Ikeguchi, M.Kochi, M.Kamada, H.Shigematsu, A.Tsutsumi, N.Adachi, T.Shibata, M.Yamamoto, M.Kikkawa, T.Senda, Y.Isobe, U.Ohto, T.Shimizu. Structural Analysis Reveals TLR7 Dynamics Underlying Antagonism. Nat Commun V. 11 5204 2020.
ISSN: ESSN 2041-1723
PubMed: 33060576
DOI: 10.1038/S41467-020-19025-Z