Fluorine »
PDB 6lub-6mii »
6m9l »
Fluorine in PDB 6m9l: Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-B]Pyridine-2-One Based P38 Map Kinase Inhibitors By Scaffold Hopping - Compound 10
Enzymatic activity of Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-B]Pyridine-2-One Based P38 Map Kinase Inhibitors By Scaffold Hopping - Compound 10
All present enzymatic activity of Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-B]Pyridine-2-One Based P38 Map Kinase Inhibitors By Scaffold Hopping - Compound 10:
2.7.11.24;
2.7.11.24;
Protein crystallography data
The structure of Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-B]Pyridine-2-One Based P38 Map Kinase Inhibitors By Scaffold Hopping - Compound 10, PDB code: 6m9l
was solved by
W.Lane,
K.Okada,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 49.38 / 2.45 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 68.674, 71.046, 74.562, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 21.3 / 27 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-B]Pyridine-2-One Based P38 Map Kinase Inhibitors By Scaffold Hopping - Compound 10
(pdb code 6m9l). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-B]Pyridine-2-One Based P38 Map Kinase Inhibitors By Scaffold Hopping - Compound 10, PDB code: 6m9l:
Jump to Fluorine binding site number: 1; 2;
In total 2 binding sites of Fluorine where determined in the Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-B]Pyridine-2-One Based P38 Map Kinase Inhibitors By Scaffold Hopping - Compound 10, PDB code: 6m9l:
Jump to Fluorine binding site number: 1; 2;
Fluorine binding site 1 out of 2 in 6m9l
Go back to
Fluorine Binding Sites List in 6m9l
Fluorine binding site 1 out
of 2 in the Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-B]Pyridine-2-One Based P38 Map Kinase Inhibitors By Scaffold Hopping - Compound 10
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-B]Pyridine-2-One Based P38 Map Kinase Inhibitors By Scaffold Hopping - Compound 10 within 5.0Å range:
|
Fluorine binding site 2 out of 2 in 6m9l
Go back to
Fluorine Binding Sites List in 6m9l
Fluorine binding site 2 out
of 2 in the Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-B]Pyridine-2-One Based P38 Map Kinase Inhibitors By Scaffold Hopping - Compound 10
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-B]Pyridine-2-One Based P38 Map Kinase Inhibitors By Scaffold Hopping - Compound 10 within 5.0Å range:
|
Reference:
A.Kaieda,
M.Takahashi,
H.Fukuda,
R.Okamoto,
S.Morimoto,
M.Gotoh,
T.Miyazaki,
Y.Hori,
S.Unno,
T.Kawamoto,
T.Tanaka,
S.Itono,
T.Takagi,
H.Sugimoto,
K.Okada,
G.Snell,
R.Bertsch,
J.Nguyen,
B.C.Sang,
S.Miwatashi.
Structure-Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-B]Pyridin-2-One-Based P38 Map Kinase Inhibitors: Part 1. Chemmedchem V. 14 1022 2019.
ISSN: ESSN 1860-7187
PubMed: 30945818
DOI: 10.1002/CMDC.201900129
Page generated: Tue Jul 15 13:06:45 2025
ISSN: ESSN 1860-7187
PubMed: 30945818
DOI: 10.1002/CMDC.201900129
Last articles
Mg in 7BGIMg in 7BLX
Mg in 7BLZ
Mg in 7BOD
Mg in 7BNR
Mg in 7BNK
Mg in 7BMC
Mg in 7BM9
Mg in 7BM8
Mg in 7BM6
