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Fluorine in PDB 6pde: Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 40
Enzymatic activity of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 40
All present enzymatic activity of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 40:
2.3.1.48;
2.3.1.48;
Protein crystallography data
The structure of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 40, PDB code: 6pde
was solved by
S.J.Hermans,
M.W.Parker,
T.Thomas,
J.B.Baell,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 43.14 / 2.22 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 46.081, 56.383, 122.684, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 18.2 / 20.9 |
Other elements in 6pde:
The structure of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 40 also contains other interesting chemical elements:
| Zinc | (Zn) | 1 atom |
| Sodium | (Na) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 40
(pdb code 6pde). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 40, PDB code: 6pde:
In total only one binding site of Fluorine was determined in the Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 40, PDB code: 6pde:
Fluorine binding site 1 out of 1 in 6pde
Go back to
Fluorine Binding Sites List in 6pde
Fluorine binding site 1 out
of 1 in the Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 40
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Myst Acetyltransferase Domain in Complex with Inhibitor 40 within 5.0Å range:
|
Reference:
D.L.Priebbenow,
D.J.Leaver,
N.Nguyen,
B.Cleary,
H.R.Lagiakos,
J.Sanchez,
L.Xue,
F.Huang,
Y.Sun,
P.Mujumdar,
R.Mudududdla,
S.Varghese,
S.Teguh,
S.A.Charman,
K.L.White,
D.M.Shackleford,
K.Katneni,
M.Cuellar,
J.M.Strasser,
J.L.Dahlin,
M.A.Walters,
I.P.Street,
B.J.Monahan,
K.E.Jarman,
H.Jousset Sabroux,
H.Falk,
M.C.Chung,
S.J.Hermans,
N.L.Downer,
M.W.Parker,
A.K.Voss,
T.Thomas,
J.B.Baell.
Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, As Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem. 2020.
ISSN: ISSN 0022-2623
PubMed: 32118427
DOI: 10.1021/ACS.JMEDCHEM.9B02071
Page generated: Tue Jul 15 14:35:05 2025
ISSN: ISSN 0022-2623
PubMed: 32118427
DOI: 10.1021/ACS.JMEDCHEM.9B02071
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