|
Atomistry » Fluorine » PDB 6q13-6qhw » 6qef | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 6q13-6qhw » 6qef » |
Fluorine in PDB 6qef: Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-Phenyl-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro-BenzylamideEnzymatic activity of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-Phenyl-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro-Benzylamide
All present enzymatic activity of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-Phenyl-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro-Benzylamide:
3.4.11.18; Protein crystallography data
The structure of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-Phenyl-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro-Benzylamide, PDB code: 6qef
was solved by
D.Musil,
T.Heinrich,
M.Lehmann,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 6qef:
The structure of Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-Phenyl-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro-Benzylamide also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-Phenyl-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro-Benzylamide
(pdb code 6qef). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-Phenyl-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro-Benzylamide, PDB code: 6qef: Fluorine binding site 1 out of 1 in 6qefGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Crystal Structure of Human Methionine Aminopeptidase-2 in Complex with An Inhibitor (S)-3-Hydroxy-2-Oxo-1-Phenyl-Pyrrolidine-3-Carboxylic Acid 3-Chloro-5-Fluoro-Benzylamide
![]() Mono view ![]() Stereo pair view
Reference:
T.Heinrich,
J.Seenisamy,
B.Blume,
J.Bomke,
M.Calderini,
U.Eckert,
M.Friese-Hamim,
R.Kohl,
M.Lehmann,
B.Leuthner,
D.Musil,
F.Rohdich,
F.T.Zenke.
Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (Metap-2) Inhibitors. J.Med.Chem. V. 62 5025 2019.
Page generated: Tue Jul 15 15:00:39 2025
ISSN: ISSN 0022-2623 PubMed: 30939017 DOI: 10.1021/ACS.JMEDCHEM.9B00041 |
Last articlesK in 9HKXK in 9HKY K in 9HKW K in 9HFO K in 9HFN K in 9HI3 K in 9HFM K in 9HAC K in 9GXH K in 9HAG |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |