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Fluorine in PDB 6u6c: Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form
Enzymatic activity of Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form
All present enzymatic activity of Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form:
4.2.1.20;
4.2.1.20;
Protein crystallography data
The structure of Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form, PDB code: 6u6c
was solved by
C.Chang,
K.Michalska,
N.I.Maltseva,
R.Jedrzejczak,
P.Mccarren,
P.P.Nag,
A.Joachimiak,
Center For Structural Genomics Of Infectious Diseases(Csgid),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.88 / 2.40 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 135.106, 159.226, 164.973, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 15.3 / 19.5 |
Other elements in 6u6c:
The structure of Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form also contains other interesting chemical elements:
| Potassium | (K) | 8 atoms |
| Sodium | (Na) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form
(pdb code 6u6c). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form, PDB code: 6u6c:
Jump to Fluorine binding site number: 1; 2; 3; 4;
In total 4 binding sites of Fluorine where determined in the Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form, PDB code: 6u6c:
Jump to Fluorine binding site number: 1; 2; 3; 4;
Fluorine binding site 1 out of 4 in 6u6c
Go back to
Fluorine Binding Sites List in 6u6c
Fluorine binding site 1 out
of 4 in the Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form within 5.0Å range:
|
Fluorine binding site 2 out of 4 in 6u6c
Go back to
Fluorine Binding Sites List in 6u6c
Fluorine binding site 2 out
of 4 in the Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form within 5.0Å range:
|
Fluorine binding site 3 out of 4 in 6u6c
Go back to
Fluorine Binding Sites List in 6u6c
Fluorine binding site 3 out
of 4 in the Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form within 5.0Å range:
|
Fluorine binding site 4 out of 4 in 6u6c
Go back to
Fluorine Binding Sites List in 6u6c
Fluorine binding site 4 out
of 4 in the Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Tryptophan Synthase From M. Tuberculosis - Aminoacrylate- and GSK2-Bound Form within 5.0Å range:
|
Reference:
K.Michalska,
C.Chang,
N.I.Maltseva,
R.Jedrzejczak,
G.T.Robertson,
F.Gusovsky,
P.Mccarren,
S.L.Schreiber,
P.P.Nag,
A.Joachimiak.
Allosteric Inhibitors of Mycobacterium Tuberculosis Tryptophan Synthase. Protein Sci. V. 29 779 2020.
ISSN: ESSN 1469-896X
PubMed: 31930594
DOI: 10.1002/PRO.3825
Page generated: Tue Jul 15 16:09:32 2025
ISSN: ESSN 1469-896X
PubMed: 31930594
DOI: 10.1002/PRO.3825
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