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Fluorine in PDB 6ujz: Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp

Enzymatic activity of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp

All present enzymatic activity of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp:
2.7.7.49; 2.7.7.7; 3.1.26.13;

Protein crystallography data

The structure of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp, PDB code: 6ujz was solved by E.B.Lansdon, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.34 / 2.56
Space group C 2 2 21
Cell size a, b, c (Å), α, β, γ (°) 168.277, 168.829, 102.548, 90.00, 90.00, 90.00
R / Rfree (%) 18.5 / 23.6

Other elements in 6ujz:

The structure of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp also contains other interesting chemical elements:

Magnesium (Mg) 1 atom

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp (pdb code 6ujz). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp, PDB code: 6ujz:

Fluorine binding site 1 out of 1 in 6ujz

Go back to Fluorine Binding Sites List in 6ujz
Fluorine binding site 1 out of 1 in the Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Hiv-1 Wild-Type Reverse Transcriptase-Dna Complex with (+)-Ftc-Tp within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F604

b:51.2
occ:1.00
FAJ A:N8G604 0.0 51.2 1.0
CAU A:N8G604 1.3 51.6 1.0
CAT A:N8G604 2.4 51.3 1.0
CAK A:N8G604 2.4 49.4 1.0
NAA A:N8G604 2.6 56.0 1.0
NH1 A:ARG72 3.5 69.4 1.0
C5 P:DOC822 3.5 45.6 1.0
NH2 A:ARG72 3.5 47.7 1.0
CZ A:ARG72 3.5 57.5 1.0
NAN A:N8G604 3.6 48.3 1.0
C4 P:DOC822 3.6 45.9 1.0
NAY A:N8G604 3.6 48.9 1.0
C6 P:DOC822 3.7 49.7 1.0
N3 P:DOC822 3.9 52.2 1.0
N1 P:DOC822 4.1 47.0 1.0
N4 P:DOC822 4.1 46.1 1.0
CAV A:N8G604 4.1 47.5 1.0
C2 P:DOC822 4.1 50.9 1.0
NE A:ARG72 4.3 56.9 1.0
OAH A:N8G604 4.4 49.5 1.0
OAO A:N8G604 4.5 48.3 1.0
C1' P:DOC822 4.8 49.9 1.0
CAX A:N8G604 4.9 44.2 1.0
OAP A:N8G604 4.9 47.5 1.0
O2 P:DOC822 4.9 52.9 1.0
C2' P:DOC822 5.0 51.3 1.0
PBA A:N8G604 5.0 48.1 1.0

Reference:

M.Hung, E.J.Tokarsky, L.Lagpacan, L.Zhang, Z.Suo, E.B.Lansdon. Elucidating Molecular Interactions of L-Nucleotides with Hiv-1 Reverse Transcriptase and Mechanism of M184V-Caused Drug Resistance Commun Biol V. 2 2019.
ISSN: ESSN 2399-3642
DOI: 10.1038/S42003-019-0706-X
Page generated: Fri Aug 2 02:34:30 2024

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