Fluorine in PDB 7axp: Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 2

The structure of Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 2, PDB code: 7axp was solved by L.Werel, L.-O.Essen, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	64.77 / 2.43
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	99.24, 99.24, 98.52, 90, 90, 120
R / Rfree (%)	26.7 / 33.1

The binding sites of Fluorine atom in the Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 2 (pdb code 7axp). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 2, PDB code: 7axp:
Jump to Fluorine binding site number: 1; 2; 3; 4;

Fluorine binding site 1 out of 4 in the Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 2 within 5.0Å range: probe atom residue distance (Å) B Occ B:F7 b:108.3 occ:1.00 FA2 B:S7Z7 0.0 108.3 1.0 CA2 B:S7Z7 1.3 88.2 1.0 FB2 B:S7Z7 2.0 99.6 1.0 CA3 B:S7Z7 2.2 83.8 1.0 CA1 B:S7Z7 2.4 85.9 1.0 CB2 B:S7Z7 2.6 91.1 1.0 NB1 B:S7Z7 2.9 93.1 1.0 CB1 B:S7Z7 2.9 89.4 1.0 NA1 B:S7Z7 2.9 91.4 1.0 CA4 B:S7Z7 3.5 81.5 1.0 CB3 B:S7Z7 3.6 90.1 1.0 CA6 B:S7Z7 3.6 87.6 1.0 CA5 B:S7Z7 4.0 84.1 1.0 CB6 B:S7Z7 4.1 95.6 1.0 CB4 B:S7Z7 4.6 89.4 1.0 CE1 B:DPN5 4.6 61.6 1.0 CA B:S7Z7 4.7 76.8 1.0 CD1 B:DPN5 4.7 59.5 1.0 CB5 B:S7Z7 4.8 91.1 1.0 FA6 B:S7Z7 4.8 91.8 1.0 FB6 B:S7Z7 4.9 98.1 1.0

Fluorine binding site 2 out of 4 in the Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 2 within 5.0Å range: probe atom residue distance (Å) B Occ B:F7 b:91.8 occ:1.00 FA6 B:S7Z7 0.0 91.8 1.0 CA6 B:S7Z7 1.3 87.6 1.0 CA5 B:S7Z7 2.3 84.1 1.0 CA1 B:S7Z7 2.4 85.9 1.0 NA1 B:S7Z7 3.0 91.4 1.0 CA4 B:S7Z7 3.6 81.5 1.0 CA2 B:S7Z7 3.7 88.2 1.0 CE1 B:DPN5 3.9 61.6 1.0 CZ B:DPN5 4.1 58.6 1.0 CA3 B:S7Z7 4.1 83.8 1.0 FB6 B:S7Z7 4.2 98.1 1.0 NB1 B:S7Z7 4.3 93.1 1.0 CB6 B:S7Z7 4.7 95.6 1.0 CB1 B:S7Z7 4.8 89.4 1.0 FA2 B:S7Z7 4.8 108.3 1.0 CA B:S7Z7 4.9 76.8 1.0

Fluorine binding site 3 out of 4 in the Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 2 within 5.0Å range: probe atom residue distance (Å) B Occ B:F7 b:99.6 occ:1.00 FB2 B:S7Z7 0.0 99.6 1.0 CB2 B:S7Z7 1.4 91.1 1.0 FA2 B:S7Z7 2.0 108.3 1.0 CB3 B:S7Z7 2.3 90.1 1.0 CB1 B:S7Z7 2.4 89.4 1.0 NB1 B:S7Z7 2.9 93.1 1.0 CA2 B:S7Z7 3.1 88.2 1.0 CB4 B:S7Z7 3.6 89.4 1.0 CB6 B:S7Z7 3.6 95.6 1.0 NA1 B:S7Z7 3.8 91.4 1.0 CA1 B:S7Z7 3.9 85.9 1.0 CA3 B:S7Z7 4.1 83.8 1.0 CB5 B:S7Z7 4.1 91.1 1.0 FB6 B:S7Z7 4.7 98.1 1.0 CB B:S7Z7 4.9 80.5 1.0 NAD B:EDN6 4.9 85.3 1.0

Fluorine binding site 4 out of 4 in the Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 2


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Structural Characterisation of WDR5:Cs-VIP8 Interaction in Cis State 2 within 5.0Å range: probe atom residue distance (Å) B Occ B:F7 b:98.1 occ:1.00 FB6 B:S7Z7 0.0 98.1 1.0 CB6 B:S7Z7 1.4 95.6 1.0 CB1 B:S7Z7 2.3 89.4 1.0 CB5 B:S7Z7 2.4 91.1 1.0 NB1 B:S7Z7 2.6 93.1 1.0 NA1 B:S7Z7 2.8 91.4 1.0 CB2 B:S7Z7 3.6 91.1 1.0 CA1 B:S7Z7 3.6 85.9 1.0 CB4 B:S7Z7 3.7 89.4 1.0 CB3 B:S7Z7 4.1 90.1 1.0 FA6 B:S7Z7 4.2 91.8 1.0 CE1 B:DPN5 4.2 61.6 1.0 CA6 B:S7Z7 4.2 87.6 1.0 CZ B:DPN5 4.4 58.6 1.0 CA2 B:S7Z7 4.5 88.2 1.0 FB2 B:S7Z7 4.7 99.6 1.0 FA2 B:S7Z7 4.9 108.3 1.0 CB B:S7Z7 4.9 80.5 1.0 OB B:S7Z7 5.0 77.6 1.0

L.Albert, J.Nagpal, W.Steinchen, L.Zhang, L.Werel, N.Djokovic, D.Ruzic, M.Hoffarth, J.Xu, J.Kaspareit, F.Abendroth, A.Royant, G.Bange, K.Nikolic, S.Ryu, Y.Dou, L.-O.Essen, O.Vazquez. Bistable Photoswitch Allows in Vivo Control of Hematopoiesis To Be Published.