Fluorine in PDB 7b0s: TRPC4 in Complex with Inhibitor Gfb-8438

The structure of TRPC4 in Complex with Inhibitor Gfb-8438 also contains other interesting chemical elements:

Calcium	(Ca)	4 atoms
Chlorine	(Cl)	4 atoms

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Fluorine atom in the TRPC4 in Complex with Inhibitor Gfb-8438 (pdb code 7b0s). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 12 binding sites of Fluorine where determined in the TRPC4 in Complex with Inhibitor Gfb-8438, PDB code: 7b0s:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 12 in the TRPC4 in Complex with Inhibitor Gfb-8438


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of TRPC4 in Complex with Inhibitor Gfb-8438 within 5.0Å range: probe atom residue distance (Å) B Occ A:F1001 b:70.1 occ:1.00 F1 A:S9Q1001 0.0 70.1 1.0 C16 A:S9Q1001 1.4 70.1 1.0 F2 A:S9Q1001 2.2 70.1 1.0 F3 A:S9Q1001 2.2 70.1 1.0 C15 A:S9Q1001 2.4 70.1 1.0 C9 A:S9Q1001 2.9 70.1 1.0 C10 A:S9Q1001 3.0 70.1 1.0 C8 A:S9Q1001 3.1 70.1 1.0 N4 A:S9Q1001 3.2 70.1 1.0 C14 A:S9Q1001 3.5 70.1 1.0 C7 A:S9Q1001 3.5 70.1 1.0 CE1 A:PHE413 4.3 68.5 1.0 C11 A:S9Q1001 4.3 70.1 1.0 C1 A:S9Q1001 4.4 70.1 1.0 C13 A:S9Q1001 4.7 70.1 1.0 N1 A:S9Q1001 4.8 70.1 1.0 CZ A:PHE413 4.9 68.5 1.0 C12 A:S9Q1001 5.0 70.1 1.0

Fluorine binding site 2 out of 12 in the TRPC4 in Complex with Inhibitor Gfb-8438


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of TRPC4 in Complex with Inhibitor Gfb-8438 within 5.0Å range: probe atom residue distance (Å) B Occ A:F1001 b:70.1 occ:1.00 F2 A:S9Q1001 0.0 70.1 1.0 C16 A:S9Q1001 1.4 70.1 1.0 F1 A:S9Q1001 2.2 70.1 1.0 F3 A:S9Q1001 2.2 70.1 1.0 C15 A:S9Q1001 2.3 70.1 1.0 C14 A:S9Q1001 2.6 70.1 1.0 CB A:HIS369 3.0 54.0 1.0 O A:HIS369 3.5 54.0 1.0 C A:HIS369 3.5 54.0 1.0 CG A:HIS369 3.5 54.0 1.0 C10 A:S9Q1001 3.6 70.1 1.0 CA A:HIS369 3.7 54.0 1.0 ND1 A:HIS369 3.8 54.0 1.0 C13 A:S9Q1001 4.0 70.1 1.0 OH A:TYR646 4.1 47.8 1.0 N A:THR370 4.2 47.9 1.0 C9 A:S9Q1001 4.3 70.1 1.0 CD2 A:HIS369 4.5 54.0 1.0 CA A:THR370 4.7 47.9 1.0 C11 A:S9Q1001 4.7 70.1 1.0 OG A:SER372 4.8 50.6 1.0 CE1 A:HIS369 4.8 54.0 1.0 C8 A:S9Q1001 4.9 70.1 1.0 C12 A:S9Q1001 4.9 70.1 1.0 N4 A:S9Q1001 5.0 70.1 1.0

Fluorine binding site 3 out of 12 in the TRPC4 in Complex with Inhibitor Gfb-8438


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of TRPC4 in Complex with Inhibitor Gfb-8438 within 5.0Å range: probe atom residue distance (Å) B Occ A:F1001 b:70.1 occ:1.00 F3 A:S9Q1001 0.0 70.1 1.0 C16 A:S9Q1001 1.4 70.1 1.0 F2 A:S9Q1001 2.2 70.1 1.0 F1 A:S9Q1001 2.2 70.1 1.0 C15 A:S9Q1001 2.4 70.1 1.0 OH A:TYR646 3.1 47.8 1.0 C10 A:S9Q1001 3.1 70.1 1.0 C9 A:S9Q1001 3.1 70.1 1.0 C14 A:S9Q1001 3.4 70.1 1.0 ND1 A:HIS369 3.9 54.0 1.0 N4 A:S9Q1001 4.2 70.1 1.0 CZ A:TYR646 4.3 47.8 1.0 CB A:HIS369 4.3 54.0 1.0 C11 A:S9Q1001 4.3 70.1 1.0 CG A:HIS369 4.4 54.0 1.0 C13 A:S9Q1001 4.6 70.1 1.0 CE1 A:HIS369 4.7 54.0 1.0 C8 A:S9Q1001 4.7 70.1 1.0 CE2 A:TYR646 4.8 47.8 1.0 C12 A:S9Q1001 4.9 70.1 1.0

Fluorine binding site 4 out of 12 in the TRPC4 in Complex with Inhibitor Gfb-8438


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of TRPC4 in Complex with Inhibitor Gfb-8438 within 5.0Å range: probe atom residue distance (Å) B Occ B:F1001 b:70.5 occ:1.00 F1 B:S9Q1001 0.0 70.5 1.0 C16 B:S9Q1001 1.4 70.5 1.0 F2 B:S9Q1001 2.2 70.5 1.0 F3 B:S9Q1001 2.2 70.5 1.0 C15 B:S9Q1001 2.4 70.5 1.0 C9 B:S9Q1001 2.9 70.5 1.0 C10 B:S9Q1001 3.0 70.5 1.0 C8 B:S9Q1001 3.1 70.5 1.0 N4 B:S9Q1001 3.2 70.5 1.0 C14 B:S9Q1001 3.5 70.5 1.0 C7 B:S9Q1001 3.5 70.5 1.0 CE1 B:PHE413 4.3 68.8 1.0 C11 B:S9Q1001 4.3 70.5 1.0 C1 B:S9Q1001 4.4 70.5 1.0 C13 B:S9Q1001 4.7 70.5 1.0 N1 B:S9Q1001 4.8 70.5 1.0 CZ B:PHE413 4.9 68.8 1.0 C12 B:S9Q1001 5.0 70.5 1.0

Fluorine binding site 5 out of 12 in the TRPC4 in Complex with Inhibitor Gfb-8438


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of TRPC4 in Complex with Inhibitor Gfb-8438 within 5.0Å range: probe atom residue distance (Å) B Occ B:F1001 b:70.5 occ:1.00 F2 B:S9Q1001 0.0 70.5 1.0 C16 B:S9Q1001 1.4 70.5 1.0 F1 B:S9Q1001 2.2 70.5 1.0 F3 B:S9Q1001 2.2 70.5 1.0 C15 B:S9Q1001 2.3 70.5 1.0 C14 B:S9Q1001 2.6 70.5 1.0 CB B:HIS369 3.0 54.1 1.0 O B:HIS369 3.5 54.1 1.0 C B:HIS369 3.5 54.1 1.0 CG B:HIS369 3.5 54.1 1.0 C10 B:S9Q1001 3.6 70.5 1.0 CA B:HIS369 3.7 54.1 1.0 ND1 B:HIS369 3.8 54.1 1.0 C13 B:S9Q1001 4.0 70.5 1.0 OH B:TYR646 4.1 48.0 1.0 N B:THR370 4.2 48.1 1.0 C9 B:S9Q1001 4.3 70.5 1.0 CD2 B:HIS369 4.5 54.1 1.0 CA B:THR370 4.7 48.1 1.0 C11 B:S9Q1001 4.7 70.5 1.0 OG B:SER372 4.8 50.6 1.0 CE1 B:HIS369 4.8 54.1 1.0 C8 B:S9Q1001 4.9 70.5 1.0 C12 B:S9Q1001 4.9 70.5 1.0 N4 B:S9Q1001 5.0 70.5 1.0

Fluorine binding site 6 out of 12 in the TRPC4 in Complex with Inhibitor Gfb-8438


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of TRPC4 in Complex with Inhibitor Gfb-8438 within 5.0Å range: probe atom residue distance (Å) B Occ B:F1001 b:70.5 occ:1.00 F3 B:S9Q1001 0.0 70.5 1.0 C16 B:S9Q1001 1.4 70.5 1.0 F2 B:S9Q1001 2.2 70.5 1.0 F1 B:S9Q1001 2.2 70.5 1.0 C15 B:S9Q1001 2.4 70.5 1.0 OH B:TYR646 3.1 48.0 1.0 C10 B:S9Q1001 3.1 70.5 1.0 C9 B:S9Q1001 3.1 70.5 1.0 C14 B:S9Q1001 3.4 70.5 1.0 ND1 B:HIS369 3.9 54.1 1.0 N4 B:S9Q1001 4.2 70.5 1.0 CZ B:TYR646 4.3 48.0 1.0 CB B:HIS369 4.3 54.1 1.0 C11 B:S9Q1001 4.3 70.5 1.0 CG B:HIS369 4.4 54.1 1.0 C13 B:S9Q1001 4.6 70.5 1.0 CE1 B:HIS369 4.7 54.1 1.0 C8 B:S9Q1001 4.7 70.5 1.0 CE2 B:TYR646 4.8 48.0 1.0 C12 B:S9Q1001 4.9 70.5 1.0

Fluorine binding site 7 out of 12 in the TRPC4 in Complex with Inhibitor Gfb-8438


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of TRPC4 in Complex with Inhibitor Gfb-8438 within 5.0Å range: probe atom residue distance (Å) B Occ C:F1001 b:70.4 occ:1.00 F1 C:S9Q1001 0.0 70.4 1.0 C16 C:S9Q1001 1.4 70.4 1.0 F2 C:S9Q1001 2.2 70.4 1.0 F3 C:S9Q1001 2.2 70.4 1.0 C15 C:S9Q1001 2.4 70.4 1.0 C9 C:S9Q1001 2.9 70.4 1.0 C10 C:S9Q1001 3.0 70.4 1.0 C8 C:S9Q1001 3.1 70.4 1.0 N4 C:S9Q1001 3.2 70.4 1.0 C14 C:S9Q1001 3.5 70.4 1.0 C7 C:S9Q1001 3.5 70.4 1.0 CE1 C:PHE413 4.3 68.6 1.0 C11 C:S9Q1001 4.3 70.4 1.0 C1 C:S9Q1001 4.4 70.4 1.0 C13 C:S9Q1001 4.7 70.4 1.0 N1 C:S9Q1001 4.8 70.4 1.0 CZ C:PHE413 4.9 68.6 1.0 C12 C:S9Q1001 5.0 70.4 1.0

Fluorine binding site 8 out of 12 in the TRPC4 in Complex with Inhibitor Gfb-8438


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of TRPC4 in Complex with Inhibitor Gfb-8438 within 5.0Å range: probe atom residue distance (Å) B Occ C:F1001 b:70.4 occ:1.00 F2 C:S9Q1001 0.0 70.4 1.0 C16 C:S9Q1001 1.4 70.4 1.0 F1 C:S9Q1001 2.2 70.4 1.0 F3 C:S9Q1001 2.2 70.4 1.0 C15 C:S9Q1001 2.3 70.4 1.0 C14 C:S9Q1001 2.6 70.4 1.0 CB C:HIS369 3.0 53.9 1.0 O C:HIS369 3.5 53.9 1.0 C C:HIS369 3.5 53.9 1.0 CG C:HIS369 3.5 53.9 1.0 C10 C:S9Q1001 3.6 70.4 1.0 CA C:HIS369 3.7 53.9 1.0 ND1 C:HIS369 3.8 53.9 1.0 C13 C:S9Q1001 4.0 70.4 1.0 OH C:TYR646 4.1 47.6 1.0 N C:THR370 4.2 47.8 1.0 C9 C:S9Q1001 4.3 70.4 1.0 CD2 C:HIS369 4.5 53.9 1.0 CA C:THR370 4.7 47.8 1.0 C11 C:S9Q1001 4.7 70.4 1.0 OG C:SER372 4.8 50.3 1.0 CE1 C:HIS369 4.8 53.9 1.0 C8 C:S9Q1001 4.9 70.4 1.0 C12 C:S9Q1001 4.9 70.4 1.0 N4 C:S9Q1001 5.0 70.4 1.0

Fluorine binding site 9 out of 12 in the TRPC4 in Complex with Inhibitor Gfb-8438


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of TRPC4 in Complex with Inhibitor Gfb-8438 within 5.0Å range: probe atom residue distance (Å) B Occ C:F1001 b:70.4 occ:1.00 F3 C:S9Q1001 0.0 70.4 1.0 C16 C:S9Q1001 1.4 70.4 1.0 F2 C:S9Q1001 2.2 70.4 1.0 F1 C:S9Q1001 2.2 70.4 1.0 C15 C:S9Q1001 2.4 70.4 1.0 OH C:TYR646 3.1 47.6 1.0 C10 C:S9Q1001 3.1 70.4 1.0 C9 C:S9Q1001 3.1 70.4 1.0 C14 C:S9Q1001 3.4 70.4 1.0 ND1 C:HIS369 3.9 53.9 1.0 N4 C:S9Q1001 4.2 70.4 1.0 CZ C:TYR646 4.3 47.6 1.0 CB C:HIS369 4.3 53.9 1.0 C11 C:S9Q1001 4.3 70.4 1.0 CG C:HIS369 4.4 53.9 1.0 C13 C:S9Q1001 4.6 70.4 1.0 CE1 C:HIS369 4.7 53.9 1.0 C8 C:S9Q1001 4.7 70.4 1.0 CE2 C:TYR646 4.8 47.6 1.0 C12 C:S9Q1001 4.9 70.4 1.0

Fluorine binding site 10 out of 12 in the TRPC4 in Complex with Inhibitor Gfb-8438


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of TRPC4 in Complex with Inhibitor Gfb-8438 within 5.0Å range: probe atom residue distance (Å) B Occ D:F1001 b:70.2 occ:1.00 F1 D:S9Q1001 0.0 70.2 1.0 C16 D:S9Q1001 1.4 70.2 1.0 F2 D:S9Q1001 2.2 70.2 1.0 F3 D:S9Q1001 2.2 70.2 1.0 C15 D:S9Q1001 2.4 70.2 1.0 C9 D:S9Q1001 2.9 70.2 1.0 C10 D:S9Q1001 3.0 70.2 1.0 C8 D:S9Q1001 3.1 70.2 1.0 N4 D:S9Q1001 3.2 70.2 1.0 C14 D:S9Q1001 3.5 70.2 1.0 C7 D:S9Q1001 3.5 70.2 1.0 CE1 D:PHE413 4.3 68.4 1.0 C11 D:S9Q1001 4.3 70.2 1.0 C1 D:S9Q1001 4.4 70.2 1.0 C13 D:S9Q1001 4.7 70.2 1.0 N1 D:S9Q1001 4.8 70.2 1.0 CZ D:PHE413 4.9 68.4 1.0 C12 D:S9Q1001 5.0 70.2 1.0

D.Vinayagam, D.Quentin, J.Yu-Strzelczyk, O.Sitsel, F.Merino, M.Stabrin, O.Hofnagel, M.Yu, M.W.Ledeboer, G.Nagel, G.Malojcic, S.Raunser. Structural Basis of TRPC4 Regulation By Calmodulin and Pharmacological Agents. Elife V. 9 2020.
ISSN: ESSN 2050-084X
PubMed: 33236980
DOI: 10.7554/ELIFE.60603