Fluorine in PDB 7bss: Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in E1ALF State

The structure of Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in E1ALF State also contains other interesting chemical elements:

Magnesium	(Mg)	1 atom
Aluminium	(Al)	1 atom

The binding sites of Fluorine atom in the Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in E1ALF State (pdb code 7bss). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in E1ALF State, PDB code: 7bss:
Jump to Fluorine binding site number: 1; 2; 3; 4;

Fluorine binding site 1 out of 4 in the Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in E1ALF State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in E1ALF State within 5.0Å range: probe atom residue distance (Å) B Occ A:F1101 b:61.6 occ:1.00 F1 A:ALF1101 0.0 61.6 1.0 AL A:ALF1101 1.8 61.6 1.0 N A:GLY675 2.5 74.6 1.0 F4 A:ALF1101 2.5 61.6 1.0 F3 A:ALF1101 2.5 61.6 1.0 OD2 A:ASP409 2.8 57.8 1.0 CA A:GLY675 3.2 74.6 1.0 C A:THR674 3.5 70.3 1.0 NZ A:LYS795 3.6 66.7 1.0 F2 A:ALF1101 3.6 61.6 1.0 CG A:ASP409 3.7 57.8 1.0 OG1 A:THR674 3.7 70.3 1.0 CA A:THR674 3.7 70.3 1.0 OG1 A:THR411 3.8 63.5 1.0 C A:GLY675 3.9 74.6 1.0 OD1 A:ASP409 4.0 57.8 1.0 N A:ASP676 4.2 86.0 1.0 CB A:THR674 4.3 70.3 1.0 CE A:LYS795 4.5 66.7 1.0 O A:LEU673 4.5 57.7 1.0 O A:THR674 4.6 70.3 1.0 O A:GLY675 4.7 74.6 1.0 N A:THR411 4.7 63.5 1.0 N A:LYS410 4.8 66.4 1.0 N A:THR674 4.9 70.3 1.0 CB A:ASP409 4.9 57.8 1.0

Fluorine binding site 2 out of 4 in the Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in E1ALF State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in E1ALF State within 5.0Å range: probe atom residue distance (Å) B Occ A:F1101 b:61.6 occ:1.00 F2 A:ALF1101 0.0 61.6 1.0 AL A:ALF1101 1.8 61.6 1.0 MG A:MG1102 1.8 61.1 1.0 OD1 A:ASP409 2.3 57.8 1.0 F4 A:ALF1101 2.5 61.6 1.0 F3 A:ALF1101 2.6 61.6 1.0 CG A:ASP409 3.0 57.8 1.0 O A:THR411 3.0 63.5 1.0 OD2 A:ASP409 3.1 57.8 1.0 OD1 A:ASP816 3.5 58.6 1.0 F1 A:ALF1101 3.6 61.6 1.0 OG1 A:THR411 3.6 63.5 1.0 OD2 A:ASP820 3.7 61.2 1.0 C A:THR411 4.2 63.5 1.0 OD1 A:ASN819 4.3 64.7 1.0 N A:GLY817 4.4 62.6 1.0 CB A:ASP409 4.4 57.8 1.0 CG A:ASP820 4.4 61.2 1.0 OE2 A:GLU837 4.5 77.2 1.0 OD1 A:ASP820 4.5 61.2 1.0 CA A:GLY817 4.5 62.6 1.0 CG A:ASP816 4.7 58.6 1.0 CB A:THR411 4.7 63.5 1.0 CG A:ASN819 4.8 64.7 1.0 N A:THR411 4.8 63.5 1.0 CA A:THR411 4.8 63.5 1.0 ND2 A:ASN819 4.9 64.7 1.0 NZ A:LYS795 5.0 66.7 1.0

Fluorine binding site 3 out of 4 in the Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in E1ALF State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in E1ALF State within 5.0Å range: probe atom residue distance (Å) B Occ A:F1101 b:61.6 occ:1.00 F3 A:ALF1101 0.0 61.6 1.0 AL A:ALF1101 1.8 61.6 1.0 F1 A:ALF1101 2.5 61.6 1.0 F2 A:ALF1101 2.6 61.6 1.0 OD2 A:ASP409 3.0 57.8 1.0 ND2 A:ASN819 3.1 64.7 1.0 CG A:ASN819 3.2 64.7 1.0 NZ A:LYS795 3.2 66.7 1.0 OD1 A:ASN819 3.4 64.7 1.0 F4 A:ALF1101 3.6 61.6 1.0 OD1 A:ASP820 3.7 61.2 1.0 CG A:ASP409 3.9 57.8 1.0 CB A:ASN819 3.9 64.7 1.0 OD1 A:ASP409 4.0 57.8 1.0 OD2 A:ASP820 4.3 61.2 1.0 CG A:ASP820 4.4 61.2 1.0 MG A:MG1102 4.4 61.1 1.0 N A:GLY675 4.5 74.6 1.0 CE A:LYS795 4.6 66.7 1.0 CA A:GLY675 4.7 74.6 1.0 OG1 A:THR411 4.7 63.5 1.0 CA A:ASN819 5.0 64.7 1.0

Fluorine binding site 4 out of 4 in the Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in E1ALF State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryo-Em Structure of A Human ATP11C-CDC50A Flippase in E1ALF State within 5.0Å range: probe atom residue distance (Å) B Occ A:F1101 b:61.6 occ:1.00 F4 A:ALF1101 0.0 61.6 1.0 AL A:ALF1101 1.8 61.6 1.0 OG1 A:THR411 2.1 63.5 1.0 OD1 A:ASP409 2.4 57.8 1.0 F2 A:ALF1101 2.5 61.6 1.0 F1 A:ALF1101 2.5 61.6 1.0 N A:THR411 2.7 63.5 1.0 O A:THR411 2.7 63.5 1.0 CG A:ASP409 2.9 57.8 1.0 OD2 A:ASP409 2.9 57.8 1.0 CB A:THR411 3.1 63.5 1.0 CA A:THR411 3.1 63.5 1.0 MG A:MG1102 3.2 61.1 1.0 C A:THR411 3.3 63.5 1.0 F3 A:ALF1101 3.6 61.6 1.0 C A:LYS410 3.7 66.4 1.0 N A:LYS410 3.7 66.4 1.0 C A:ASP409 4.0 57.8 1.0 CG2 A:THR411 4.0 63.5 1.0 CA A:LYS410 4.1 66.4 1.0 CB A:ASP409 4.2 57.8 1.0 O A:ASP409 4.3 57.8 1.0 OG1 A:THR674 4.4 70.3 1.0 CB A:LYS410 4.5 66.4 1.0 CA A:ASP409 4.5 57.8 1.0 N A:GLY412 4.5 63.8 1.0 O A:LYS410 4.6 66.4 1.0 N A:GLY675 4.7 74.6 1.0

H.Nakanishi, T.Nishizawa, K.Segawa, O.Nureki, Y.Fujiyoshi, S.Nagata, K.Abe. Transport Cycle of Plasma Membrane Flippase ATP11C By Cryo-Em. Cell Rep V. 32 08208 2020.
ISSN: ESSN 2211-1247
PubMed: 32997992
DOI: 10.1016/J.CELREP.2020.108208