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Atomistry » Fluorine » PDB 7cl1-7db8 » 7cmw | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 7cl1-7db8 » 7cmw » |
Fluorine in PDB 7cmw: Complex Structure of PARP1 Catalytic Domain with PamiparibEnzymatic activity of Complex Structure of PARP1 Catalytic Domain with Pamiparib
All present enzymatic activity of Complex Structure of PARP1 Catalytic Domain with Pamiparib:
2.4.2.30; Protein crystallography data
The structure of Complex Structure of PARP1 Catalytic Domain with Pamiparib, PDB code: 7cmw
was solved by
Y.C.Feng,
H.Peng,
Y.Hong,
Y.Liu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Complex Structure of PARP1 Catalytic Domain with Pamiparib
(pdb code 7cmw). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Complex Structure of PARP1 Catalytic Domain with Pamiparib, PDB code: 7cmw: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 7cmwGo back to![]() ![]()
Fluorine binding site 1 out
of 2 in the Complex Structure of PARP1 Catalytic Domain with Pamiparib
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 2 in 7cmwGo back to![]() ![]()
Fluorine binding site 2 out
of 2 in the Complex Structure of PARP1 Catalytic Domain with Pamiparib
![]() Mono view ![]() Stereo pair view
Reference:
H.Wang,
B.Ren,
Y.Liu,
B.Jiang,
Y.Guo,
M.Wei,
L.Luo,
X.Kuang,
M.Qiu,
L.Lv,
H.Xu,
R.Qi,
H.Yan,
D.Xu,
Z.Wang,
C.X.Huo,
Y.Zhu,
Y.Zhao,
Y.Wu,
Z.Qin,
D.Su,
T.Tang,
F.Wang,
X.Sun,
Y.Feng,
H.Peng,
X.Wang,
Y.Gao,
Y.Liu,
W.Gong,
F.Yu,
X.Liu,
L.Wang,
C.Zhou.
Discovery of Pamiparib (Bgb-290), A Potent and Selective Poly (Adp-Ribose) Polymerase (Parp) Inhibitor in Clinical Development. J.Med.Chem. 2020.
Page generated: Tue Jul 15 18:57:32 2025
ISSN: ISSN 0022-2623 PubMed: 33264017 DOI: 10.1021/ACS.JMEDCHEM.0C01346 |
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