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Fluorine in PDB 7cqe: Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Azd-7762
Enzymatic activity of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Azd-7762
All present enzymatic activity of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Azd-7762:
2.7.10.1;
2.7.10.1;
Protein crystallography data
The structure of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Azd-7762, PDB code: 7cqe
was solved by
T.H.Park,
B.I.Lee,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 43.53 / 2.69 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 116.118, 69.203, 92.606, 90.00, 118.42, 90.00 |
| R / Rfree (%) | 19.7 / 25.9 |
Other elements in 7cqe:
The structure of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Azd-7762 also contains other interesting chemical elements:
| Chlorine | (Cl) | 6 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Azd-7762
(pdb code 7cqe). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Azd-7762, PDB code: 7cqe:
Jump to Fluorine binding site number: 1; 2;
In total 2 binding sites of Fluorine where determined in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Azd-7762, PDB code: 7cqe:
Jump to Fluorine binding site number: 1; 2;
Fluorine binding site 1 out of 2 in 7cqe
Go back to
Fluorine Binding Sites List in 7cqe
Fluorine binding site 1 out
of 2 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Azd-7762
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Azd-7762 within 5.0Å range:
|
Fluorine binding site 2 out of 2 in 7cqe
Go back to
Fluorine Binding Sites List in 7cqe
Fluorine binding site 2 out
of 2 in the Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Azd-7762
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of the Catalytic Domain of the Proto-Oncogene Tyrosine-Protein Kinase Mer in Complex with Azd-7762 within 5.0Å range:
|
Reference:
T.H.Park,
S.H.Bae,
S.M.Bong,
S.E.Ryu,
H.Jang,
B.I.Lee.
Crystal Structure of the Kinase Domain of Mertk in Complex with AZD7762 Provides Clues For Structure-Based Drug Development. Int J Mol Sci V. 21 2020.
ISSN: ESSN 1422-0067
PubMed: 33114206
DOI: 10.3390/IJMS21217878
Page generated: Fri Aug 2 06:14:19 2024
ISSN: ESSN 1422-0067
PubMed: 33114206
DOI: 10.3390/IJMS21217878
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