Fluorine in PDB 7dfp: Human Dopamine D2 Receptor in Complex with Spiperone

The structure of Human Dopamine D2 Receptor in Complex with Spiperone, PDB code: 7dfp was solved by D.Im, T.Shimamura, S.Iwata, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.12 / 3.10
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	161.9, 40.5, 165.9, 90, 116.5, 90
R / Rfree (%)	18.5 / 21.7

The binding sites of Fluorine atom in the Human Dopamine D2 Receptor in Complex with Spiperone (pdb code 7dfp). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Human Dopamine D2 Receptor in Complex with Spiperone, PDB code: 7dfp:

Fluorine binding site 1 out of 1 in the Human Dopamine D2 Receptor in Complex with Spiperone


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Human Dopamine D2 Receptor in Complex with Spiperone within 5.0Å range: probe atom residue distance (Å) B Occ A:F1201 b:114.3 occ:1.00 F29 A:SIP1201 0.0 114.3 1.0 C26 A:SIP1201 1.4 114.4 1.0 C27 A:SIP1201 2.4 115.1 1.0 C25 A:SIP1201 2.4 114.3 1.0 CD1 A:PHE198 3.4 100.8 1.0 CZ A:PHE382 3.6 105.3 1.0 C28 A:SIP1201 3.6 116.5 1.0 C24 A:SIP1201 3.6 116.0 1.0 CD1 A:ILE122 3.7 109.9 1.0 CB A:ILE122 3.9 108.8 1.0 CG2 A:ILE122 4.0 110.8 1.0 C23 A:SIP1201 4.1 115.8 1.0 CE1 A:PHE198 4.2 101.8 1.0 CB A:PHE198 4.3 104.9 1.0 CG A:PHE198 4.3 102.2 1.0 O A:SER197 4.3 115.6 1.0 CE1 A:PHE390 4.3 117.1 1.0 CE2 A:PHE382 4.3 107.2 1.0 CG1 A:ILE122 4.3 107.7 1.0 CZ A:PHE390 4.3 117.6 1.0 O A:CYS118 4.4 112.7 1.0 CE1 A:PHE382 4.5 105.5 1.0 CA A:PHE198 4.5 112.9 1.0 C A:SER197 5.0 113.9 1.0 C A:CYS118 5.0 105.3 1.0

D.Im, A.Inoue, T.Fujiwara, T.Nakane, Y.Yamanaka, T.Uemura, C.Mori, Y.Shiimura, K.T.Kimura, H.Asada, N.Nomura, T.Tanaka, A.Yamashita, E.Nango, K.Tono, F.M.N.Kadji, J.Aoki, S.Iwata, T.Shimamura. Structure of the Dopamine D 2 Receptor in Complex with the Antipsychotic Drug Spiperone. Nat Commun V. 11 6442 2020.
ISSN: ESSN 2041-1723
PubMed: 33353947
DOI: 10.1038/S41467-020-20221-0