Fluorine »
PDB 7g6a-7gb8 »
7gb3 »
Fluorine in PDB 7gb3: Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Dav-Cri-3EDB475E-6 (Mpro-X10172)
Enzymatic activity of Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Dav-Cri-3EDB475E-6 (Mpro-X10172)
All present enzymatic activity of Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Dav-Cri-3EDB475E-6 (Mpro-X10172):
3.4.22.69;
3.4.22.69;
Protein crystallography data
The structure of Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Dav-Cri-3EDB475E-6 (Mpro-X10172), PDB code: 7gb3
was solved by
D.Fearon,
A.Aimon,
J.C.Aschenbrenner,
B.H.Balcomb,
F.K.R.Bertram,
J.Brandao-Neto,
A.Dias,
A.Douangamath,
L.Dunnett,
A.S.Godoy,
T.J.Gorrie-Stone,
L.Koekemoer,
T.Krojer,
R.M.Lithgo,
P.Lukacik,
P.G.Marples,
H.Mikolajek,
E.Nelson,
C.D.Owen,
A.J.Powell,
V.L.Rangel,
R.Skyner,
C.M.Strain-Damerell,
W.Thompson,
C.W.E.Tomlinson,
C.Wild,
M.A.Walsh,
F.Von Delft,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 55.00 / 1.38 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 112.809, 52.778, 44.402, 90, 102.82, 90 |
| R / Rfree (%) | 16.6 / 20.6 |
Other elements in 7gb3:
The structure of Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Dav-Cri-3EDB475E-6 (Mpro-X10172) also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Dav-Cri-3EDB475E-6 (Mpro-X10172)
(pdb code 7gb3). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Dav-Cri-3EDB475E-6 (Mpro-X10172), PDB code: 7gb3:
In total only one binding site of Fluorine was determined in the Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Dav-Cri-3EDB475E-6 (Mpro-X10172), PDB code: 7gb3:
Fluorine binding site 1 out of 1 in 7gb3
Go back to
Fluorine Binding Sites List in 7gb3
Fluorine binding site 1 out
of 1 in the Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Dav-Cri-3EDB475E-6 (Mpro-X10172)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Group Deposition Sars-Cov-2 Main Protease in Complex with Inhibitors From the Covid Moonshot -- Crystal Structure of Sars-Cov-2 Main Protease in Complex with Dav-Cri-3EDB475E-6 (Mpro-X10172) within 5.0Å range:
|
Reference:
M.L.Boby,
D.Fearon,
M.Ferla,
M.Filep,
L.Koekemoer,
M.C.Robinson,
The Covid Moonshot Consortium,
J.D.Chodera,
A.A.Lee,
N.London,
A.Von Delft,
F.Von Delft.
Open Science Discovery of Potent Noncovalent Sars-Cov-2 Main Protease Inhibitors Science 2023.
ISSN: ESSN 1095-9203
DOI: 10.1126/SCIENCE.ABO7201
Page generated: Tue Jul 15 20:09:06 2025
ISSN: ESSN 1095-9203
DOI: 10.1126/SCIENCE.ABO7201
Last articles
Mn in 9LJUMn in 9LJW
Mn in 9LJS
Mn in 9LJR
Mn in 9LJT
Mn in 9LJV
Mg in 9UA2
Mg in 9R96
Mg in 9VM1
Mg in 9P01
