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Atomistry » Fluorine » PDB 7k6z-7kpb » 7kk4 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 7k6z-7kpb » 7kk4 » |
Fluorine in PDB 7kk4: Structure of the Catalytic Domain of PARP1 in Complex with OlaparibEnzymatic activity of Structure of the Catalytic Domain of PARP1 in Complex with Olaparib
All present enzymatic activity of Structure of the Catalytic Domain of PARP1 in Complex with Olaparib:
2.4.2.30; Protein crystallography data
The structure of Structure of the Catalytic Domain of PARP1 in Complex with Olaparib, PDB code: 7kk4
was solved by
K.S.Gajiwala,
K.Ryan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of the Catalytic Domain of PARP1 in Complex with Olaparib
(pdb code 7kk4). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Structure of the Catalytic Domain of PARP1 in Complex with Olaparib, PDB code: 7kk4: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 7kk4Go back to![]() ![]()
Fluorine binding site 1 out
of 2 in the Structure of the Catalytic Domain of PARP1 in Complex with Olaparib
![]() Mono view ![]() Stereo pair view
Fluorine binding site 2 out of 2 in 7kk4Go back to![]() ![]()
Fluorine binding site 2 out
of 2 in the Structure of the Catalytic Domain of PARP1 in Complex with Olaparib
![]() Mono view ![]() Stereo pair view
Reference:
K.Ryan,
B.Bolanos,
M.Smith,
P.Palde,
P.D.Cuenca,
T.L.Vanarsdale,
S.Niessen,
L.Zhang,
D.Behenna,
M.A.Ornelas,
K.T.Tran,
S.Kaiser,
L.Lum,
A.Stewart,
K.S.Gajiwala.
Dissecting the Molecular Determinants of Clinical PARP1 Inhibitor Selectivity For TANKYRASE1. J.Biol.Chem. 2020.
Page generated: Tue Jul 15 20:50:19 2025
ISSN: ESSN 1083-351X PubMed: 33361107 DOI: 10.1074/JBC.RA120.016573 |
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