Fluorine in PDB 7ku7: Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048. Cluster Identified By 3-Dimensional Variability Analysis in Cryosparc.

The structure of Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048. Cluster Identified By 3-Dimensional Variability Analysis in Cryosparc. also contains other interesting chemical elements:

Magnesium	(Mg)	4 atoms
Chlorine	(Cl)	2 atoms
Zinc	(Zn)	2 atoms

The binding sites of Fluorine atom in the Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048. Cluster Identified By 3-Dimensional Variability Analysis in Cryosparc. (pdb code 7ku7). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048. Cluster Identified By 3-Dimensional Variability Analysis in Cryosparc., PDB code: 7ku7:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048. Cluster Identified By 3-Dimensional Variability Analysis in Cryosparc.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048. Cluster Identified By 3-Dimensional Variability Analysis in Cryosparc. within 5.0Å range: probe atom residue distance (Å) B Occ J:F401 b:147.9 occ:1.00 FAH J:ZZX401 0.0 147.9 1.0 CAT J:ZZX401 1.4 147.9 1.0 CAV J:ZZX401 2.4 147.9 1.0 CAJ J:ZZX401 2.4 147.9 1.0 CLAI J:ZZX401 2.9 147.9 1.0 N1 I:DG4 3.5 144.1 1.0 CAL J:ZZX401 3.6 147.9 1.0 CAK J:ZZX401 3.6 147.9 1.0 CG A:GLN151 3.6 146.8 1.0 N4 J:DC35 3.8 146.2 1.0 C2 I:DG4 3.8 144.1 1.0 C6 I:DG4 3.9 144.1 1.0 C4 J:DC35 3.9 146.2 1.0 N2 I:DG4 4.1 144.1 1.0 CAU J:ZZX401 4.1 147.9 1.0 O6 I:DG4 4.2 144.1 1.0 C5 J:DC35 4.2 146.2 1.0 O A:SER150 4.3 145.0 1.0 CB A:GLN151 4.4 146.8 1.0 N3 J:DC35 4.5 146.2 1.0 C5 I:DG4 4.5 144.1 1.0 N3 I:DG4 4.6 144.1 1.0 CA A:GLN151 4.7 146.8 1.0 C4 I:DG4 4.8 144.1 1.0 CD A:GLN151 4.8 146.8 1.0 C6 J:DC35 4.9 146.2 1.0 NE2 A:GLN151 4.9 146.8 1.0

Fluorine binding site 2 out of 2 in the Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048. Cluster Identified By 3-Dimensional Variability Analysis in Cryosparc.


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048. Cluster Identified By 3-Dimensional Variability Analysis in Cryosparc. within 5.0Å range: probe atom residue distance (Å) B Occ L:F401 b:138.8 occ:1.00 FAH L:ZZX401 0.0 138.8 1.0 CAT L:ZZX401 1.3 138.8 1.0 CAV L:ZZX401 2.4 138.8 1.0 CAJ L:ZZX401 2.4 138.8 1.0 CLAI L:ZZX401 2.9 138.8 1.0 CG E:GLN151 3.5 134.5 1.0 N1 K:DG4 3.6 141.6 1.0 CAL L:ZZX401 3.6 138.8 1.0 CAK L:ZZX401 3.6 138.8 1.0 C2 K:DG4 3.8 141.6 1.0 N4 L:DC35 3.9 145.2 1.0 N2 K:DG4 4.0 141.6 1.0 CB E:GLN151 4.0 134.5 1.0 C6 K:DG4 4.1 141.6 1.0 C4 L:DC35 4.1 145.2 1.0 CAU L:ZZX401 4.1 138.8 1.0 O E:SER150 4.2 138.5 1.0 CA E:GLN151 4.4 134.5 1.0 C5 L:DC35 4.4 145.2 1.0 N3 K:DG4 4.5 141.6 1.0 O6 K:DG4 4.5 141.6 1.0 N3 L:DC35 4.6 145.2 1.0 C5 K:DG4 4.7 141.6 1.0 CD E:GLN151 4.8 134.5 1.0 C4 K:DG4 4.8 141.6 1.0 C E:SER150 5.0 138.5 1.0 NE2 E:GLN151 5.0 134.5 1.0

K.K.Pandey, S.Bera, K.Shi, H.Aihara, D.P.Grandgenett, M.J.Rau, A.V.Oleru, J.A.J.Fitzpatrick, A.N.Engelman. Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048 Commun Biol 2021.
ISSN: ESSN 2399-3642
DOI: 10.1038/S42003-021-01855-2