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Fluorine in PDB 7ld3: Cryo-Em Structure of the Human Adenosine A1 Receptor-GI2-Protein Complex Bound to Its Endogenous Agonist and An Allosteric Ligand

Other elements in 7ld3:

The structure of Cryo-Em Structure of the Human Adenosine A1 Receptor-GI2-Protein Complex Bound to Its Endogenous Agonist and An Allosteric Ligand also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Cryo-Em Structure of the Human Adenosine A1 Receptor-GI2-Protein Complex Bound to Its Endogenous Agonist and An Allosteric Ligand (pdb code 7ld3). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Cryo-Em Structure of the Human Adenosine A1 Receptor-GI2-Protein Complex Bound to Its Endogenous Agonist and An Allosteric Ligand, PDB code: 7ld3:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in 7ld3

Go back to Fluorine Binding Sites List in 7ld3
Fluorine binding site 1 out of 6 in the Cryo-Em Structure of the Human Adenosine A1 Receptor-GI2-Protein Complex Bound to Its Endogenous Agonist and An Allosteric Ligand


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of the Human Adenosine A1 Receptor-GI2-Protein Complex Bound to Its Endogenous Agonist and An Allosteric Ligand within 5.0Å range:
probe atom residue distance (Å) B Occ
R:F402

b:76.2
occ:1.00
F R:XTD402 0.0 76.2 1.0
C14 R:XTD402 1.3 76.2 1.0
F2 R:XTD402 2.1 76.2 1.0
F1 R:XTD402 2.1 76.2 1.0
C13 R:XTD402 2.4 76.2 1.0
C12 R:XTD402 3.1 76.2 1.0
C15 R:XTD402 3.3 76.2 1.0
C11 R:XTD402 4.4 76.2 1.0
C16 R:XTD402 4.5 76.2 1.0
C18 R:XTD402 5.0 76.2 1.0

Fluorine binding site 2 out of 6 in 7ld3

Go back to Fluorine Binding Sites List in 7ld3
Fluorine binding site 2 out of 6 in the Cryo-Em Structure of the Human Adenosine A1 Receptor-GI2-Protein Complex Bound to Its Endogenous Agonist and An Allosteric Ligand


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of the Human Adenosine A1 Receptor-GI2-Protein Complex Bound to Its Endogenous Agonist and An Allosteric Ligand within 5.0Å range:
probe atom residue distance (Å) B Occ
R:F402

b:76.2
occ:1.00
F1 R:XTD402 0.0 76.2 1.0
C14 R:XTD402 1.3 76.2 1.0
F2 R:XTD402 2.1 76.2 1.0
F R:XTD402 2.1 76.2 1.0
C13 R:XTD402 2.4 76.2 1.0
C15 R:XTD402 2.7 76.2 1.0
C12 R:XTD402 3.6 76.2 1.0
C16 R:XTD402 4.1 76.2 1.0
C11 R:XTD402 4.7 76.2 1.0
F5 R:XTD402 4.8 76.2 1.0
C18 R:XTD402 4.9 76.2 1.0

Fluorine binding site 3 out of 6 in 7ld3

Go back to Fluorine Binding Sites List in 7ld3
Fluorine binding site 3 out of 6 in the Cryo-Em Structure of the Human Adenosine A1 Receptor-GI2-Protein Complex Bound to Its Endogenous Agonist and An Allosteric Ligand


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of the Human Adenosine A1 Receptor-GI2-Protein Complex Bound to Its Endogenous Agonist and An Allosteric Ligand within 5.0Å range:
probe atom residue distance (Å) B Occ
R:F402

b:76.2
occ:1.00
F2 R:XTD402 0.0 76.2 1.0
C14 R:XTD402 1.3 76.2 1.0
F1 R:XTD402 2.1 76.2 1.0
F R:XTD402 2.1 76.2 1.0
C13 R:XTD402 2.4 76.2 1.0
C12 R:XTD402 2.8 76.2 1.0
C15 R:XTD402 3.5 76.2 1.0
C11 R:XTD402 4.2 76.2 1.0
C6 R:XTD402 4.3 76.2 1.0
C16 R:XTD402 4.7 76.2 1.0
C5 R:XTD402 4.8 76.2 1.0
CE2 R:PHE275 4.8 62.8 1.0
C18 R:XTD402 4.9 76.2 1.0

Fluorine binding site 4 out of 6 in 7ld3

Go back to Fluorine Binding Sites List in 7ld3
Fluorine binding site 4 out of 6 in the Cryo-Em Structure of the Human Adenosine A1 Receptor-GI2-Protein Complex Bound to Its Endogenous Agonist and An Allosteric Ligand


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryo-Em Structure of the Human Adenosine A1 Receptor-GI2-Protein Complex Bound to Its Endogenous Agonist and An Allosteric Ligand within 5.0Å range:
probe atom residue distance (Å) B Occ
R:F402

b:76.2
occ:1.00
F3 R:XTD402 0.0 76.2 1.0
C17 R:XTD402 1.3 76.2 1.0
F4 R:XTD402 2.1 76.2 1.0
F5 R:XTD402 2.1 76.2 1.0
C16 R:XTD402 2.4 76.2 1.0
C18 R:XTD402 2.7 76.2 1.0
SD R:MET283 3.3 68.2 1.0
C15 R:XTD402 3.6 76.2 1.0
C3 R:XTD402 4.0 76.2 1.0
C11 R:XTD402 4.1 76.2 1.0
CE R:MET283 4.2 68.2 1.0
C4 R:XTD402 4.4 76.2 1.0
C2 R:XTD402 4.5 76.2 1.0
CG R:MET283 4.7 68.2 1.0
C13 R:XTD402 4.7 76.2 1.0
CL R:XTD402 4.8 76.2 1.0
C12 R:XTD402 4.9 76.2 1.0

Fluorine binding site 5 out of 6 in 7ld3

Go back to Fluorine Binding Sites List in 7ld3
Fluorine binding site 5 out of 6 in the Cryo-Em Structure of the Human Adenosine A1 Receptor-GI2-Protein Complex Bound to Its Endogenous Agonist and An Allosteric Ligand


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Cryo-Em Structure of the Human Adenosine A1 Receptor-GI2-Protein Complex Bound to Its Endogenous Agonist and An Allosteric Ligand within 5.0Å range:
probe atom residue distance (Å) B Occ
R:F402

b:76.2
occ:1.00
F4 R:XTD402 0.0 76.2 1.0
C17 R:XTD402 1.3 76.2 1.0
F3 R:XTD402 2.1 76.2 1.0
F5 R:XTD402 2.1 76.2 1.0
C16 R:XTD402 2.3 76.2 1.0
C15 R:XTD402 3.1 76.2 1.0
C18 R:XTD402 3.3 76.2 1.0
C13 R:XTD402 4.4 76.2 1.0
C11 R:XTD402 4.5 76.2 1.0
SD R:MET283 4.7 68.2 1.0
C12 R:XTD402 5.0 76.2 1.0
CE R:MET283 5.0 68.2 1.0

Fluorine binding site 6 out of 6 in 7ld3

Go back to Fluorine Binding Sites List in 7ld3
Fluorine binding site 6 out of 6 in the Cryo-Em Structure of the Human Adenosine A1 Receptor-GI2-Protein Complex Bound to Its Endogenous Agonist and An Allosteric Ligand


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Cryo-Em Structure of the Human Adenosine A1 Receptor-GI2-Protein Complex Bound to Its Endogenous Agonist and An Allosteric Ligand within 5.0Å range:
probe atom residue distance (Å) B Occ
R:F402

b:76.2
occ:1.00
F5 R:XTD402 0.0 76.2 1.0
C17 R:XTD402 1.3 76.2 1.0
F3 R:XTD402 2.1 76.2 1.0
F4 R:XTD402 2.1 76.2 1.0
C16 R:XTD402 2.4 76.2 1.0
C15 R:XTD402 2.8 76.2 1.0
C18 R:XTD402 3.5 76.2 1.0
C13 R:XTD402 4.2 76.2 1.0
CL R:XTD402 4.4 76.2 1.0
C4 R:XTD402 4.4 76.2 1.0
C3 R:XTD402 4.7 76.2 1.0
C11 R:XTD402 4.7 76.2 1.0
F1 R:XTD402 4.8 76.2 1.0
C5 R:XTD402 4.8 76.2 1.0
C12 R:XTD402 4.9 76.2 1.0

Reference:

C.J.Draper-Joyce, R.Bhola, J.Wang, A.Bhattarai, A.T.N.Nguyen, I.Cowie-Kent, K.O'sullivan, H.Venugopal, C.Valant, D.M.Thal, D.Wootten, N.Panel, J.Carlsson, M.J.Christie, P.Scammells, P.Sexton, L.T.May, Y.Miao, R.Danev, A.Glukhova, W.L.Imlach, A.Christopoulos. Structural Basis of Action of An Allosteric Non-Opioid Analgesic Drug To Be Published.
Page generated: Tue Jul 15 21:11:37 2025

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