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Fluorine in PDB 7m0y: Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Trametinib

Enzymatic activity of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Trametinib

All present enzymatic activity of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Trametinib:
2.7.11.1; 2.7.12.2;

Protein crystallography data

The structure of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Trametinib, PDB code: 7m0y was solved by K.Li, G.Gonzalez Del-Pino, B.H.Ha, E.Park, M.J.Eck, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.08 / 3.45
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 116.716, 116.716, 129.483, 90, 90, 120
R / Rfree (%) 19.5 / 21.8

Other elements in 7m0y:

The structure of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Trametinib also contains other interesting chemical elements:

Iodine (I) 1 atom
Magnesium (Mg) 2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Trametinib (pdb code 7m0y). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Trametinib, PDB code: 7m0y:

Fluorine binding site 1 out of 1 in 7m0y

Go back to Fluorine Binding Sites List in 7m0y
Fluorine binding site 1 out of 1 in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Trametinib


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Trametinib within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F404

b:73.1
occ:1.00
F18 B:QOM404 0.0 73.1 1.0
C12 B:QOM404 1.4 79.0 1.0
C11 B:QOM404 2.4 68.3 1.0
C13 B:QOM404 2.4 82.1 1.0
N10 B:QOM404 2.8 64.9 1.0
CD1 B:ILE141 3.2 57.2 1.0
CG2 B:ILE141 3.2 58.4 1.0
CB B:ILE141 3.3 59.6 1.0
C16 B:QOM404 3.6 67.8 1.0
C14 B:QOM404 3.7 77.4 1.0
CG1 B:ILE141 3.8 70.0 1.0
CE B:LYS97 3.9 68.1 1.0
C15 B:QOM404 4.1 65.3 1.0
SD B:MET143 4.2 58.6 1.0
CD B:LYS97 4.2 58.3 1.0
O20 B:QOM404 4.2 81.1 1.0
C05 B:QOM404 4.3 65.3 1.0
CE B:MET143 4.4 68.5 1.0
OD2 B:ASP208 4.4 80.1 1.0
O B:ILE141 4.6 60.5 1.0
CA B:ILE141 4.6 57.7 1.0
CB B:LYS97 4.7 55.4 1.0
C B:ILE141 4.9 56.5 1.0
C09 B:QOM404 4.9 61.5 1.0
N06 B:QOM404 5.0 61.2 1.0

Reference:

K.Li, G.Gonzalez Del-Pino, B.H.Ha, E.Park, M.J.Eck. Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and Binimetinib To Be Published.
Page generated: Tue Jul 15 21:29:52 2025

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