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Fluorine in PDB 7mfd: Autoinhibited Braf:(14-3-3)2:Mek Complex with the Braf Rbd Resolved

Enzymatic activity of Autoinhibited Braf:(14-3-3)2:Mek Complex with the Braf Rbd Resolved

All present enzymatic activity of Autoinhibited Braf:(14-3-3)2:Mek Complex with the Braf Rbd Resolved:
2.7.11.1; 2.7.12.2;

Other elements in 7mfd:

The structure of Autoinhibited Braf:(14-3-3)2:Mek Complex with the Braf Rbd Resolved also contains other interesting chemical elements:

Zinc (Zn) 2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Autoinhibited Braf:(14-3-3)2:Mek Complex with the Braf Rbd Resolved (pdb code 7mfd). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Autoinhibited Braf:(14-3-3)2:Mek Complex with the Braf Rbd Resolved, PDB code: 7mfd:

Fluorine binding site 1 out of 1 in 7mfd

Go back to Fluorine Binding Sites List in 7mfd
Fluorine binding site 1 out of 1 in the Autoinhibited Braf:(14-3-3)2:Mek Complex with the Braf Rbd Resolved


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Autoinhibited Braf:(14-3-3)2:Mek Complex with the Braf Rbd Resolved within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F401

b:100.6
occ:1.00
F33 B:CHU401 0.0 100.6 1.0
C22 B:CHU401 1.3 100.6 1.0
C14 B:CHU401 2.3 100.6 1.0
C23 B:CHU401 2.4 100.6 1.0
N27 B:CHU401 2.8 100.6 1.0
C13 B:CHU401 2.8 100.6 1.0
O B:ILE216 3.5 91.6 1.0
C26 B:CHU401 3.6 100.6 1.0
N24 B:CHU401 3.6 100.6 1.0
O B:LEU215 3.7 92.9 1.0
CA B:ILE216 3.9 91.6 1.0
C25 B:CHU401 4.0 100.6 1.0
C B:ILE216 4.1 91.6 1.0
CB B:MET219 4.1 85.5 1.0
C8 B:CHU401 4.3 100.6 1.0
CG B:MET219 4.4 85.5 1.0
SD B:MET219 4.4 85.5 1.0
S28 B:CHU401 4.4 100.6 1.0
N B:ALA220 4.5 77.0 1.0
C B:LEU215 4.6 92.9 1.0
N B:ILE216 4.7 91.6 1.0
C B:MET219 4.7 85.5 1.0
CB B:ILE216 4.8 91.6 1.0
O11 B:CHU401 4.8 100.6 1.0
C30 B:CHU401 4.9 100.6 1.0
CA B:MET219 4.9 85.5 1.0
CA B:ALA220 5.0 77.0 1.0
CG2 B:ILE216 5.0 91.6 1.0
CG1 B:ILE216 5.0 91.6 1.0

Reference:

J.A.Martinez Fiesco, D.E.Durrant, D.K.Morrison, P.Zhang. Structural Insights Into the Braf Monomer-to-Dimer Transition Mediated By Ras Binding. Nat Commun V. 13 486 2022.
ISSN: ESSN 2041-1723
PubMed: 35078985
DOI: 10.1038/S41467-022-28084-3
Page generated: Tue Jul 15 21:39:43 2025

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