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Atomistry » Fluorine » PDB 7pav-7pzx » 7pqv | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 7pav-7pzx » 7pqv » |
Fluorine in PDB 7pqv: MEK1 in Complex with Compound 7Enzymatic activity of MEK1 in Complex with Compound 7
All present enzymatic activity of MEK1 in Complex with Compound 7:
2.7.12.2; Protein crystallography data
The structure of MEK1 in Complex with Compound 7, PDB code: 7pqv
was solved by
H.Moebitz,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7pqv:
The structure of MEK1 in Complex with Compound 7 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the MEK1 in Complex with Compound 7
(pdb code 7pqv). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the MEK1 in Complex with Compound 7, PDB code: 7pqv: Fluorine binding site 1 out of 1 in 7pqvGo back to![]() ![]()
Fluorine binding site 1 out
of 1 in the MEK1 in Complex with Compound 7
![]() Mono view ![]() Stereo pair view
Reference:
R.Poddutoori,
K.Aardalen,
K.Aithal,
S.S.Barahagar,
C.Belliappa,
M.Bock,
S.Chelur,
A.Gerken,
S.Gopinath,
B.Gruenenfelder,
M.Kiffe,
M.Krishnaswami,
J.Langowski,
S.Madapa,
K.Narayanan,
C.Pandit,
S.K.Panigrahi,
M.Perrone,
R.K.Potakamuri,
M.Ramachandra,
A.Ramanathan,
R.Ramos,
E.Sager,
S.Samajdar,
H.S.Subramanya,
D.S.Thimmasandra,
E.Venetsanakos,
H.Mobitz.
Discovery of MAP855, An Efficacious and Selective MEK1/2 Inhibitor with An Atp-Competitive Mode of Action. J.Med.Chem. V. 65 4350 2022.
Page generated: Tue Jul 15 22:51:50 2025
ISSN: ISSN 0022-2623 PubMed: 35195996 DOI: 10.1021/ACS.JMEDCHEM.1C02192 |
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