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Atomistry » Fluorine » PDB 7slr-7t21 » 7sv1 » |
Fluorine in PDB 7sv1: Carbonic Anhydrase IX-Mimic Complexed with 3-((2-((Naphthalen-2- Ylmethyl)(4-Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino) Propanoic AcidEnzymatic activity of Carbonic Anhydrase IX-Mimic Complexed with 3-((2-((Naphthalen-2- Ylmethyl)(4-Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino) Propanoic Acid
All present enzymatic activity of Carbonic Anhydrase IX-Mimic Complexed with 3-((2-((Naphthalen-2- Ylmethyl)(4-Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino) Propanoic Acid:
4.2.1.1; Protein crystallography data
The structure of Carbonic Anhydrase IX-Mimic Complexed with 3-((2-((Naphthalen-2- Ylmethyl)(4-Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino) Propanoic Acid, PDB code: 7sv1
was solved by
J.E.Combs,
R.Mckenna,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7sv1:
The structure of Carbonic Anhydrase IX-Mimic Complexed with 3-((2-((Naphthalen-2- Ylmethyl)(4-Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino) Propanoic Acid also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Carbonic Anhydrase IX-Mimic Complexed with 3-((2-((Naphthalen-2- Ylmethyl)(4-Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino) Propanoic Acid
(pdb code 7sv1). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Carbonic Anhydrase IX-Mimic Complexed with 3-((2-((Naphthalen-2- Ylmethyl)(4-Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino) Propanoic Acid, PDB code: 7sv1: Fluorine binding site 1 out of 1 in 7sv1Go back to![]() ![]()
Fluorine binding site 1 out
of 1 in the Carbonic Anhydrase IX-Mimic Complexed with 3-((2-((Naphthalen-2- Ylmethyl)(4-Sulfamoylphenethyl)Amino)-2-Oxoethyl)(Phenethyl)Amino) Propanoic Acid
![]() Mono view ![]() Stereo pair view
Reference:
A.Bonardi,
S.Bua,
J.Combs,
C.Lomelino,
J.Andring,
S.M.Osman,
A.Toti,
L.Di Cesare Mannelli,
P.Gratteri,
C.Ghelardini,
R.Mckenna,
A.Nocentini,
C.T.Supuran.
The Three-Tails Approach As A New Strategy to Improve Selectivity of Action of Sulphonamide Inhibitors Against Tumour-Associated Carbonic Anhydrase IX and XII. J Enzyme Inhib Med Chem V. 37 930 2022.
Page generated: Wed Jul 16 00:16:50 2025
ISSN: ESSN 1475-6374 PubMed: 35306936 DOI: 10.1080/14756366.2022.2053526 |
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