Fluorine in PDB 7sv7: The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Tezacaftor (Vx-661)

Enzymatic activity of The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Tezacaftor (Vx-661)

Other elements in 7sv7:

Fluorine Binding Sites:

Fluorine binding site 1 out of 3 in 7sv7

Fluorine Binding Sites List in 7sv7

Fluorine binding site 1 out of 3 in the The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Tezacaftor (Vx-661)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Tezacaftor (Vx-661) within 5.0Å range: probe atom residue distance (Å) B Occ A:F1515 b:54.2 occ:1.00 F A:CV61515 0.0 54.2 1.0 C9 A:CV61515 1.4 54.2 1.0 C8 A:CV61515 2.3 54.2 1.0 C10 A:CV61515 2.3 54.2 1.0 N1 A:CV61515 2.7 54.2 1.0 CZ3 A:TRP361 3.3 46.6 1.0 CG1 A:ILE70 3.4 56.1 1.0 CD1 A:ILE70 3.4 56.1 1.0 C11 A:CV61515 3.6 54.2 1.0 C7 A:CV61515 3.6 54.2 1.0 CH2 A:TRP361 3.7 46.6 1.0 C24 A:CV61515 4.0 54.2 1.0 C15 A:CV61515 4.0 54.2 1.0 C6 A:CV61515 4.1 54.2 1.0 CD2 A:LEU365 4.1 50.2 1.0 C19 A:CV61515 4.3 54.2 1.0 C23 A:CV61515 4.4 54.2 1.0 CE3 A:TRP361 4.5 46.6 1.0 C16 A:CV61515 4.7 54.2 1.0 N A:CV61515 4.9 54.2 1.0 CB A:ILE70 4.9 56.1 1.0 O3 A:CV61515 4.9 54.2 1.0 C20 A:CV61515 5.0 54.2 1.0

Fluorine binding site 2 out of 3 in 7sv7

Fluorine Binding Sites List in 7sv7

Fluorine binding site 2 out of 3 in the The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Tezacaftor (Vx-661)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Tezacaftor (Vx-661) within 5.0Å range: probe atom residue distance (Å) B Occ A:F1515 b:54.2 occ:1.00 F1 A:CV61515 0.0 54.2 1.0 C25 A:CV61515 1.3 54.2 1.0 F2 A:CV61515 2.1 54.2 1.0 O5 A:CV61515 2.2 54.2 1.0 O4 A:CV61515 2.2 54.2 1.0 C22 A:CV61515 3.2 54.2 1.0 C21 A:CV61515 3.3 54.2 1.0 CD2 A:TRP361 3.4 46.6 1.0 CE2 A:TRP361 3.5 46.6 1.0 CG A:TRP361 3.6 46.6 1.0 CE3 A:TRP361 3.7 46.6 1.0 CA A:TRP361 3.8 46.6 1.0 NE1 A:TRP361 3.9 46.6 1.0 CB A:SER364 3.9 51.5 1.0 CB A:ALA198 3.9 46.0 1.0 CD1 A:TRP361 3.9 46.6 1.0 OG A:SER364 4.1 51.5 1.0 CZ2 A:TRP361 4.1 46.6 1.0 O A:THR360 4.1 45.9 1.0 N A:TRP361 4.2 46.6 1.0 CZ3 A:TRP361 4.2 46.6 1.0 CB A:TRP361 4.3 46.6 1.0 C A:THR360 4.3 45.9 1.0 CH2 A:TRP361 4.4 46.6 1.0 CG2 A:THR360 4.4 45.9 1.0 C23 A:CV61515 4.5 54.2 1.0 C20 A:CV61515 4.5 54.2 1.0 C A:TRP361 4.9 46.6 1.0 CA A:ALA198 4.9 46.0 1.0 O A:TRP361 4.9 46.6 1.0 CD2 A:LEU195 4.9 50.4 1.0

Fluorine binding site 3 out of 3 in 7sv7

Fluorine Binding Sites List in 7sv7

Fluorine binding site 3 out of 3 in the The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Tezacaftor (Vx-661)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of The Complex of Phosphorylated Human Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Atp/Mg and Tezacaftor (Vx-661) within 5.0Å range: probe atom residue distance (Å) B Occ A:F1515 b:54.2 occ:1.00 F2 A:CV61515 0.0 54.2 1.0 C25 A:CV61515 1.3 54.2 1.0 F1 A:CV61515 2.1 54.2 1.0 O5 A:CV61515 2.2 54.2 1.0 O4 A:CV61515 2.2 54.2 1.0 C21 A:CV61515 2.9 54.2 1.0 C22 A:CV61515 3.0 54.2 1.0 OG A:SER364 3.3 51.5 1.0 CB A:SER364 3.6 51.5 1.0 CD2 A:LEU195 3.6 50.4 1.0 CG A:LEU195 4.0 50.4 1.0 CB A:ALA198 4.1 46.0 1.0 C20 A:CV61515 4.2 54.2 1.0 CG2 A:THR360 4.3 45.9 1.0 C23 A:CV61515 4.3 54.2 1.0 CA A:LEU195 4.6 50.4 1.0 N A:LEU195 4.8 50.4 1.0 O A:THR360 4.8 45.9 1.0 C A:GLY194 4.9 55.2 1.0 CB A:LEU195 4.9 50.4 1.0 O A:GLY194 4.9 55.2 1.0

Reference: